Functional, Anatomical, and Prognostic Correlates of Coronary Flow Velocity Reserve During Stress Echocardiography
Functional, Anatomical, and Prognostic Correlates of Coronary Flow Velocity Reserve During Stress Echocardiography
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DOI：
10.1016/j.jacc.2019.08.1046
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发表时间：
2019-11-05
影响因子：
24
通讯作者：
Picano, Eugenio
中科院分区：
文献类型：
--
作者：
Ciampi, Quirino;Zagatina, Angela;Picano, Eugenio
背景冠状动脉左前降支（LAD）冠状动脉血流速度储备（CFVR）的评估扩大了基于应力诱导的区域壁运动异常（RWMA）的应激超声心动图（SE）的风险分层潜力。目的本研究的目的是评估CFVR的可行性和功能相关因素。方法：这项前瞻性、观察性、多中心研究最初筛选了3410例已知或疑似冠状动脉疾病和/或心力衰竭患者（2061例[60%]男性，年龄63 +/- 11岁，射血分数61 +/- 9%）。在8个国家的20个认可实验室中，所有患者均接受了基于RWMA新发或恶化的SE（运动，n = 1288；血管扩张剂，n = 1860；多巴酚丁胺，n = 262）。CFVR计算为舒张期峰值血流速度的应力/休息比。对1867名患者进行了随访。结果CFVR治疗LAD的成功率为3002 / 3410，可行性为88%。减少(
BACKGROUND The assessment of coronary flow velocity reserve (CFVR) in left anterior descending coronary artery (LAD) expands the risk stratification potential of stress echocardiography (SE) based on stress-induced regional wall motion abnormalities (RWMA).OBJECTIVES The purpose of this study was to assess the feasibility and functional correlates of CFVR.METHODS This prospective, observational, multicenter study initially screened 3,410 patients (2,061 [60%] male; age 63 +/- 11 years; ejection fraction 61 +/- 9%) with known or suspected coronary artery disease and/or heart failure. All patients underwent SE (exercise, n = 1,288; vasodilator, n = 1,860; dobutamine, n = 262) based on new or worsening RWMA in 20 accredited laboratories of 8 countries. CFVR was calculated as the stress/rest ratio of diastolic peak flow velocity pulsed-Doppler assessment of LAD flow. A subset of 1,867 patients was followed up.RESULTS The success rate for CFVR on LAD was 3,002 of 3,410 (feasibility = 88%). Reduced (