Synthesis of oligonucleoside phosphorodithioates on a solid support by the H-phosphonothioate method
Synthesis of oligonucleoside phosphorodithioates on a solid support by the H-phosphonothioate method
复制标题
DOI：
10.1016/j.tet.2006.09.024
复制
发表时间：
2006-12-11
期刊：
影响因子：
2.1
通讯作者：
Kawashima, Etsuko
中科院分区：
文献类型：
--
作者：
Kamaike, Kazuo;Hirose, Kumi;Kawashima, Etsuko
采用h -膦硫酸盐方法，以双（2,6-二甲基苯基）磷酸氯酸盐作为偶联剂在固体载体上有效地合成了二硫硫酸盐型短寡核苷酸，在h -膦硫酸盐低聚物组装完成后，与标准h -膦酸盐方法一样，使用单质硫进行氧化。(c) 2006 Elsevier Ltd.版权所有。
Phosphorodithioate-type short oligonucleotides were efficiently synthesized using bis(2,6-dimethylphenyl) phosphorochloridate as a coupling agent on a solid support by application of the H-phosphonothioate method, where oxidation was facilitated using elemental sulfur following completion of H-phosphonothioate oligomer assembly, as with the standard H-phosphonate method. (c) 2006 Elsevier Ltd. All rights reserved.