Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis
Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis
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DOI：
10.3748/wjg.14.6382
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发表时间：
2008-11-07
影响因子：
4.3
通讯作者：
Ito, Tetsuhide
中科院分区：
文献类型：
--
作者：
Ino, Yoshifumi;Arita, Yoshiyuki;Ito, Tetsuhide
AIM: To evaluate the efficacy of continuous regional arterial infusion therapy (CRAI) with gabexate mesilate and antibiotics for severe acute pancreatitis (SAP).METHODS: We conducted a prospective study on patients who developed SAP with or without CRAI. Out of 18 patients fulfilled clinical diagnostic criteria for SAP in Japan, 9 patients underwent CRAI, while 9 patients underwent conventional systemic protease inhibitor and antibiotics therapy (non-CRAI). CRAI was initiated within 72 h of the onset of pancreatitis. Gabexate mesilate (2400 mg/d) was continuously administered inflammation-related parameters were examined.RESULTS: The duration of abdominal pain in the CRAI group was 1.9 +/- 0.26 d, whereas that in the non-CRAI group was 4.3 +/- 0.50. The duration of SIRS in the CRAI group was 2.2 +/- 0.22 d, whereas that in the nonCRAI group was 3.2 +/- 0.28. Abdominal pain and SIRS disappeared significantly in a short period of time after the initiation of CRAI using gabexate mesilate. The average length of hospitalization significantly differed between the CRAI and non-CRAI groups, 53.3 +/- 7.9 d and 87.4 +/- 13.9 d, respectively. During the first two weeks, levels of serum CRP and the IL6/IL10 ratio in the CRAI group tended to have a rapid decrease compared to those in the non-CRAI group.CONCLUSION: The present results suggest that CRAI using gabexate mesilate was effective against SAP. (C) 2008 The WJG Press. All rights reserved.
