The functional role and the clinical application of periostin in chronic rhinosinusitis
The functional role and the clinical application of periostin in chronic rhinosinusitis
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DOI：
10.1080/1744666x.2023.2192928
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发表时间：
2023-03
影响因子：
4.4
通讯作者：
K. Izuhara;S. Fujieda;N. Ohta
中科院分区：
文献类型：
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作者：
K. Izuhara;S. Fujieda;N. Ohta
摘要引言慢性鼻窦炎（CRS）包括几个异质性组，现在分类的基础上内源型比表型更频繁。许多旨在寻找2型CRS的有用生物标志物的研究表明，骨膜蛋白是一种有前途的替代物。提供了CRS患者中组织骨膜蛋白表达和血清骨膜蛋白的临床意义的全面概述。共病哮喘对血清骨膜蛋白和血清以外的样本中，骨膜蛋白可以检测到CRS患者的影响也进行了讨论。此外，骨膜蛋白在CRS发病机制中的功能作用进行了总结。骨膜蛋白作为2型CRS的标志性生物标志物的地位已经得到很好的确立，使我们能够通过内分型对CRS患者进行分类。血清骨膜蛋白不仅可用于CRS患者的内定型，而且可用于估计疾病严重程度、合并症、预后和对治疗的反应，特别是预测手术后复发。然而，我们如何将血清骨膜蛋白应用于CRS患者的生物制剂仍有待解决。旨在显示骨膜蛋白是CRS的治疗靶点的进一步研究正在等待中。
ABSTRACT Introduction Chronic rhinosinusitis (CRS) comprises several heterogenous groups, now classified based on endotype more often than on phenotype. A number of studies aimed at finding a useful biomarker for type 2 CRS suggest that periostin is a promising surrogate. Areas covered A comprehensive overview of the clinical significance of tissue periostin expression and serum periostin in CRS patients is provided. The effects of comorbid asthma on serum periostin and samples other than serum in which periostin can be detected in CRS patients are also discussed. Moreover, the functional roles of periostin in CRS pathogenesis are summarized. Expert opinion The position of periostin as a signature biomarker of type 2 CRS has been well established, enabling us to classify CRS patients by endotyping. Serum periostin is useful not only for endotyping CRS patients, but also for estimating disease severity, comorbidity, prognosis, and response to treatment, and in particular, predicting recurrence after surgery. However, it remains to be addressed how we apply serum periostin to using biologics for CRS patients. Further studies aimed at showing periostin to be a therapeutic target for CRS are awaited.