Spiroalanfurantones A-D, Four Eudesmanolide-Furan Sesquiterpene Adducts with a Pentacyclic 6/6/5/5/5 Skeleton from Inula helenium
Spiroalanfurantones A-D, Four Eudesmanolide-Furan Sesquiterpene Adducts with a Pentacyclic 6/6/5/5/5 Skeleton from Inula helenium
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螺阿兰呋喃酮 A-D，四种来自旋覆花氦的五环 6/6/5/5/5 骨架的桉内酯-呋喃倍半萜加合物
DOI：
10.1021/acs.orglett.9b03676
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Jianqing Yu
中科院分区：
文献类型：
--
作者：
You-Sheng Cai;Zi Wu;Jian-Rong Wang;Xiao-Qin Zheng;Jie Xu;Guofu Qiu;Jianqing Yu
从旋覆花（Inulahelenium）根中分离得到4个具有6/6/5/5/5五环骨架的桉烷内酯-呋喃倍半萜加合物Spiroalanfurantones A-D（1-4）。通过光谱数据分析和单晶X-射线衍射分析确定了它们的结构。提出了1 - 4的合理生物合成途径。生物活性测定结果表明，化合物1和2对脂多糖诱导的RAW264.7巨噬细胞产生一氧化氮有明显的抑制作用，IC 50值分别为17.3和9.5 μM。
Spiroalanfurantones A–D (1–4), four eudesmanolide–furan sesquiterpene adducts with an unprecedented pentacyclic 6/6/5/5/5 skeleton, were isolated from the roots ofInula helenium. Their structures were elucidated by spectroscopic data analysis and single-crystal X-ray diffraction analysis. The plausible biosynthetic pathway for1–4is presented. Bioassay showed that compounds1and2significantly inhibited nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages with IC50values of 17.3 and 9.5 μM, respectively.