Genome-wide approaches for cancer gene discovery.

Genome-wide approaches for cancer gene discovery.
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DOI:
10.1016/j.tibtech.2011.06.003
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发表时间:
2011-11
影响因子:
17.3
通讯作者:
Wajapeyee, Narendra
Wajapeyee, Narendra
中科院分区:
工程技术1区
文献类型:
--
作者:
Lizardi, Paul M.;Forloni, Matteo;Wajapeyee, Narendra

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One of the central aims of cancer research is to identify and characterize cancer-causing alterations in cancer genomes. In recent years, unprecedented advances in genome-wide sequencing, functional genomics technologies of RNA interference screens and methods to evaluate three-dimensional chromatin organization in vivo have resulted in important discoveries regarding human cancer. The cancer causing genes identified from these new genome-wide technologies have also provided opportunities for effective and personalized cancer therapy. In this review, we describe some of the most recent technologies for cancer gene discovery. We also provide specific examples where these technologies have proven remarkably successful in uncovering important cancer-causing alterations.
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