Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action.
Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action.
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苯妥英银：一种通过综合药理作用促进真皮伤口愈合的新型纳米化合物
作者：
Ai XY;Liu HJ;Lu C;Liang CL;Sun Y;Chen S;Sun B;Li Y;Liu YR;Zhang Q;Liu XQ;Xiao T;Jing XS;Sun T;Zhou HG;Yang C
苯妥英是一种抗癫痫药物，已被广泛用于伤口愈合。受前人研究的启发，合成了一种难溶的银纳米化合物苯妥英银(PnAg)，该化合物在组织修复中表现出良好的治疗效果，毒性低(LD50和GT；5g/kg)。体内研究表明，PnAg能促进SD大鼠和Bama小型猪皮肤创面愈合，并具有较强的抗炎作用。由于其低溶解性，PnAg在动物体内具有低毒和血液浓缩的特点。此外，PnAg还能上调Jak、STAT3和STAT3下游蛋白的启动子活性。因此，PnAg可能通过调节gp130/JAK/STAT3信号通路，成为一种有效的创面愈合治疗化合物。
Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could accelerate dermal wound healing and strong inflammation control in Sprague-Dawley rats (SD rat) and Bama minipigs. Due to its low solubility, PnAg led to low toxicity and blood enrichment in animals. Furthermore, PnAg could upregulate the promoter activity of Jak, Stat3, and Stat3 downstream proteins. Therefore, PnAg may serve as an effective therapeutic compound for wound healing through regulating the gp130/Jak/Stat3 signaling pathway.