Topical delivery of mTOR inhibitor halts scarring.
Topical delivery of mTOR inhibitor halts scarring.
复制标题
局部施用 mTOR 抑制剂可以阻止疤痕形成。
DOI：
10.1016/j.jdermsci.2019.06.008
复制
发表时间：
2019
影响因子：
4.6
通讯作者：
Squarize,CristianeH
中科院分区：
文献类型：
--
作者：
Webber,LianaP;Yip,Brian;NascimentoFilho,CarlosHVdo;Park,HaB;Castilho,RogerioM;Squarize,CristianeH
瘢痕管理被认为是一个主要的医疗需求，影响患者的大伤口，广泛烧伤，并提高遗传易感性的瘢痕形成。疤痕影响人类的健康，干扰美学，皮肤功能和身体运动的物理限制[1]。疤痕不仅限于皮肤系统（如皮肤），它还影响多个器官，如呼吸和消化（如肺和唾液腺）系统等。此外，手术干预也可能导致不希望的疤痕和纤维化，特别是在皮肤中[2]。开发针对纤维化和瘢痕形成的新型药理学策略构成了改善受影响个体生活的迫切需要。瘢痕形成的生物学是独特的，因为它在伤口闭合后和组织成熟阶段发展。目前的治疗方法效果有限，主要依赖于增强皮肤水合作用、适度缓解组织张力和防紫外线（UV）。常规治疗包括过多的手术和非手术策略，如压力疗法，硅胶，磨皮术，化学换肤，以及皮质类固醇注射，甚至使用放疗和化疗（例如，5-氟尿嘧啶或博来霉素）。大多数非处方制剂含有洋葱提取物和维生素A和E等成分;然而，文献缺乏精心设计的研究来测试其功效[3]。
Scar management is considered a major medical need affecting patients with large wounds, extensive burns, and enhanced genetic susceptibility for scar formation. Scarring impacts the human’s well-being interfering with aesthetics, skin functions, and physical restriction of the body movement [1]. Scarring is not limited to the integumentary system (eg, skin), it also affects multiple organs like the respiratory and digestive (eg, lungs and salivary glands) systems, among others. Moreover, surgical interventions can also lead to undesired scarring and fibrosis, especially in the skin [2]. The development of novel pharmacological strategies targeting fibrosis and scarring constitute an urgent need to improve the lives of affected individuals. The biology of the scar formation is unique as it develops later after wound closure and during tissue maturation phase. Such a long course of scar formation provides a unique window of opportunity for pharmacological intervention.Current therapies offer limited results and mainly rely on enhanced skin hydration, moderate relieve of tissue tension, and protection against ultraviolet (UV). Conventional treatment includes a plethora of surgical and non-surgical strategies as pressure therapy, silicone gel, dermabrasion, chemical peels, as well as corticosteroid injections, and even the use of radiation and chemotherapy (eg, 5-fluorouracil or bleomycin). Most of the overthe-counter formulations contain ingredients like onion extract and vitamins A and E; however, the literature lacks well-designed studies to test their efficacy [3].