Molecular Imaging of the Cholinergic System in Alzheimer and Lewy Body Dementias: Expanding Views.
Molecular Imaging of the Cholinergic System in Alzheimer and Lewy Body Dementias: Expanding Views.
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DOI：
10.1007/s11910-021-01140-z
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发表时间：
2021-09-20
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
脑胆碱能去神经支配是阿尔茨海默病（AD）和路易体痴呆（DLB）的主要特征。我们回顾了通过胆碱能分子成像研究评估的这两种主要类型的痴呆的地形图。一项小型荟萃分析直接比较了 AD 与 DLB 患者的囊泡乙酰胆碱转运蛋白 (VAChT) PET 扫描。 VAChT PET 研究表明，两种形式的痴呆症均存在广泛的皮质胆碱能去神经支配，而 DLB 中也存在多个皮质下结构。新颖的分析揭示了 AD 中丘脑去神经支配的证据，以及 DLB 中上丘脑、前运动/感觉运动皮质和纹状体损失的证据。地形上不同的皮质和皮质下胆碱能病变可以区分 AD 和 DLB，这里强调了新的结构。特定胆碱能投射的不同脆弱性可能与这些疾病的特定临床特征有关。更好地了解胆碱能缺陷区域胆碱能神经传递的机制和作用可能会导致对症治疗。
Brain cholinergic denervation is a major feature of Alzheimer’s disease (AD) and Dementia with Lewy bodies (DLB). We reviewed the topography of assessed by cholinergic molecular imaging study in these two major types of dementia. A small meta-analysis directly comparing vesicular acetylcholine transporter (VAChT) PET scans of AD vs. DLB patients is presented. VAChT PET studies showed evidence of extensive cortical cholinergic denervation in both forms of dementia, while multiple subcortical structures were also in DLB. Novel analysis revealed evidence of metathalamic denervation in AD, and epithalamus, premotor/sensorimotor cortical, and striatal losses in DLB. Topographically distinct cortical and subcortical cholinergic lesions can distinguish AD and DLB, and new structures have been highlighted here. Differential vulnerability of specific cholinergic projections are likely associated with specific clinical features of these disorders. Improved understanding of the mechanisms and roles of cholinergic neurotransmission in regions with cholinergic deficits may lead to symptomatic therapies.
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影响因子：
9.3
作者：
Petrou, Myria;Frey, Kirk A.;Koeppe, Robert A.
通讯作者：
Koeppe, Robert A.
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Heiss, WD
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