Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.
Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.
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最少的shred中央神经蛋白NK1受体的消融减少了GR73632诱导的呕吐。
DOI：
10.1037/a0015733
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发表时间：
2009-06
影响因子：
1.9
通讯作者：
Darmani, Nissar A.
中科院分区：
文献类型：
--
作者：
Ray, Andrew P.;Chebolu, Seetha;Ramirez, Juan;Darmani, Nissar A.
The neurocircuitry mediating the emetic reflex is still incompletely understood, and a key question is the degree to which central and/or peripheral components contribute to the overall vomiting mechanism. Having previously found a significant peripheral component in neurokinin NK1-receptor mediated emesis, we undertook this study to examine the putative central component. Adult least shrews were injected intracerebroventricularly (i.c.v.) with saline or the blood-brain barrier impermeable toxin, Stable Substance P-saporin (SSP-SAP), which ablates cells expressing NK1 receptors. After three days, shrews were challenged intraperitoneally (i.p.) with the emetogenic NK1 agonist GR73632 at different doses and vomiting and scratching behaviors quantified. Ablation of NK1-bearing cells was verified immunohistochemically. Although SSP-SAP injection reduced emesis at 2.5 and 5 mg/kg GR73632 doses, no injections completely eliminated emesis. These data demonstrate that there is a major central nervous system component, and minor peripheral nervous system component, to tachykinin-mediated vomiting. Side effects of the current generation of antiemetics could potentially be reduced by improving bioavailability of the drugs in the more potent central nervous system compartment while reducing bioavailability in the less potent peripheral compartment.
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影响因子：
3.6
作者：
DARMANI, NA;MOCK, OB;GERDES, GF
通讯作者：
GERDES, GF
影响因子：
2.9
作者：
Darmani, Nissar A.;Crim, Jennifer L.;Ramirez, Juan
通讯作者：
Ramirez, Juan
影响因子：
5
作者：
Darmani, NA;Johnson, JC
通讯作者：
Johnson, JC
影响因子：
5
作者：
Minami, M;Endo, T;Andrews, PLR
通讯作者：
Andrews, PLR
DOI：
10.1113/expphysiol.1988.sp003124
发表时间：
1988-01-01
影响因子：
--
作者：
HAWTHORN, J;OSTLER, KJ;ANDREWS, PLR
通讯作者：
ANDREWS, PLR