Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains
Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains
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DOI：
10.1152/japplphysiol.01045.2001
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发表时间：
2002-06-01
影响因子：
3.3
通讯作者：
Leinwand, LA
中科院分区：
文献类型：
--
作者：
Lerman, I;Harrison, BC;Leinwand, LA
本研究的目的是描述遗传对强迫和自愿运动表现的影响，并确定这两种范式中的表现是否受到类似遗传影响的控制。跑步机运动表现存在明显的应变差异，与所有其他品系相比，Swiss Webster (SW) 和 FVB/NJ 小鼠表现出较高的表现，而 C57BL/6J 动物表现出下降的表现。跑步机性能和自主轮性能之间没有明显的关系，但 SW 小鼠除外，它在跑步机和自主轮上都表现出了较高的性能。测量了许多特性，试图了解运动表现差异的基础。 DBA/1J 和 SW 小鼠表现出比所有其他分析品系显着更强的心肌收缩力。相反，与所有其他品系相比，BALB/cByJ 小鼠的心肌收缩力显着降低。与所有其他分析菌株相比，DBA/2J 心肌中肥厚分子指标（心房钠尿因子和 β-肌球蛋白重链）的表达显着升高。
The goal of this study was to characterize the genetic contribution to both forced and voluntary exercise performance and to determine whether performance in these two paradigms is controlled by similar genetic influences. There were marked strain differences in treadmill exercise performance, with Swiss Webster (SW) and FVB/NJ mice showing elevated performance and C57BL/6J animals showing decreased performance compared with all other strains. There was no apparent relationship between treadmill performance and voluntary wheel performance, with the exception of SW mice, which demonstrated high performances on both the treadmill and the voluntary wheel. Numerous properties were measured to attempt to understand the basis for these differences in exercise performance. DBA/1J and SW mice exhibited significantly greater cardiac contractility than all other analyzed strains. Conversely, BALB/cByJ mice exhibited significantly reduced cardiac contractility compared with all other strains. Expression of molecular indicators of hypertrophy (atrial natriuretic factor and beta-myosin heavy chain) was significantly elevated in DBA/2J myocardium compared with all other analyzed strains.