Neurochemical changes related to ageing in the rat brain and the effect of DL-α-lipoic acid
Neurochemical changes related to ageing in the rat brain and the effect of DL-α-lipoic acid
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DOI：
10.1016/s0531-5565(02)00122-5
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发表时间：
2002-12-01
影响因子：
3.9
通讯作者：
Panneerselvam, C
中科院分区：
文献类型：
--
作者：
Arivazhagan, P;Panneerselvam, C
与年龄相关的认知和运动功能障碍与涉及大脑不同区域的许多有害的形态和功能变化有关。神经递质及其受体的丧失和对神经递质的反应性的丧失是神经衰老和年龄相关疾病的关键表现。在本研究中，我们评估了 DL-α-硫辛酸对年轻和老年大鼠不同脑区神经递质的影响。研究发现老年大鼠的神经递质水平降低。此外，DL-α-硫辛酸治疗的老年大鼠显示多巴胺、血清素和去甲肾上腺素的状态有所增加。这项研究的结果提供了证据，证明 DL-α-硫辛酸（一种有效的抗氧化剂）治疗可以改善衰老过程中的神经递质。因此，可以得出结论，DL-α-硫辛酸在老年大鼠的大脑中充当有效的神经调节剂。 (C) 2002 Elsevier Science Inc. 保留所有权利。
Age-related impairments of cognitive and motor function have been linked to a number of deleterious morphological and functional changes involving different areas of the brain. Loss of neurotransmitters, their receptors and responsiveness to neurotransmitters are key manifestations of neurological ageing and age-related disorders. In the present investigation we have evaluated the effect of DL-alpha-lipoic acid on neurotransmitters in discrete brain regions of young and aged rats. The levels of neurotransmitters were found to be lowered in aged rats. Moreover, DL-alpha-lipoic acid treated aged rats showed a increase in the status of dopamine, serotonin and norepinephrine. The results of this study provide evidence that DL-alpha-lipoic acid (a potent antioxidant) treatment can improve neurotransmitters during ageing. Hence, it can be concluded that DL-alpha-lipoic acid act as a potent neuromodulator in the brain of aged rats. (C) 2002 Elsevier Science Inc. All rights reserved.