OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia.
OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia.
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DOI：
10.1016/j.oret.2017.07.022
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Huang D
中科院分区：
文献类型：
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作者：
Hagag AM;Pechauer AD;Liu L;Wang J;Zhang M;Jia Y;Huang D
使用投影分辨OCT血管造影术研究高氧下3个旁视网膜丛的自动调节反应。前瞻性队列研究。来自9名健康参与者的9只眼睛。使用商业光谱域OCT系统扫描每个参与者的一只眼睛。在基线和吸氧期间进行两次重复黄斑扫描（3 × 3 mm 2）。采用分裂谱幅度去相关算法进行血流检测。投影分辨算法用于抑制投影伪影并分辨3个不同的旁脑丛中的血流。使用Wilcoxon符号秩检验比较基线和高氧参数。使用变异系数、组内相关系数和合并标准差评估OCT血管造影测量的可靠性。从3个神经丛的每个的正面血管造影片以及从全神经丛内部视网膜板计算血流指数和血管密度。高氧导致仅深毛细血管丛的血流指数（-11%）和血管密度（-7.8%）（P < 0.001）以及全丛平板的血流指数（P = 0.015）显著降低。中间毛细血管丛和浅表血管复合体的血流指数也降低，但这些变化较小，无统计学意义。投影分辨OCT血管造影显示所有参数的会话内基线重复性良好（变异系数，0.8%-5.2%;组内相关系数，0.93-0.98）。观察到相对较大的日间响应重现性（合并标准差，1.7%-9.4%）。投影分辨OCT血管造影能够显示视网膜对高氧的自动调节反应仅影响深毛细血管丛，而不影响中间毛细血管丛或浅表血管复合体。
Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia. Prospective cohort study. Nine eyes from 9 healthy participants. One eye from each participant was scanned using a commercial spectral-domain OCT system. Two repeated macular scans (3 × 3 mm2) were acquired at baseline and during oxygen breathing. The split-spectrum amplitude-decorrelation algorithm was used to detect blood flow. The projection-resolved algorithm was used to suppress projection artifacts and resolve blood flow in 3 distinct parafoveal plexuses. The Wilcoxon signed-rank test was used to compare baseline and hyperoxic parameters. The coefficient of variation, intraclass correlation coefficient, and pooled standard deviation were used to assess the reliability of OCT angiography measurements. Flow index and vessel density were calculated from the en face angiograms of each of the 3 plexuses, as well as from the all-plexus inner retinal slab. Hyperoxia induced significant reduction in the flow index (−11%) and vessel density (−7.8%) of only the deep capillary plexus (P < 0.001) and in the flow index of the all-plexus slab (P = 0.015). The flow index also decreased in the intermediate capillary plexus and the superficial vascular complex, but these changes were small and not statistically significant. The projection-resolved OCT angiography showed good within-session baseline repeatability (coefficient of variation, 0.8%–5.2%; intraclass correlation coefficient, 0.93–0.98) in all parameters. Relatively large between-day response reproducibility was observed (pooled standard deviation, 1.7%–9.4%). Projection-resolved OCT angiography was able to show that the retinal autoregulatory response to hyperoxia affects only the deep capillary plexus, but not the intermediate capillary plexus or superficial vascular complex.