Genetic polymorphisms of GSTP1 and mEPHX correlate with oxidative stress markers and lung function in COPD
Genetic polymorphisms of GSTP1 and mEPHX correlate with oxidative stress markers and lung function in COPD
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DOI：
10.1016/j.bbrc.2007.05.076
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发表时间：
2007-07-20
影响因子：
3.1
通讯作者：
Qadar Pasha, M. A.
中科院分区：
文献类型：
--
作者：
Vibhuti, Arpana;Arif, Ehtesham;Qadar Pasha, M. A.
COPD的遗传易感性可能取决于解毒酶的变化，解毒酶激活和解毒香烟烟雾产品，否则产生氧化应激引起的发病机制。本研究采用病例对照研究方法，对202例COPD患者和136例正常人进行了GST P1基因1105 V、A114 V多态性和mEPHX基因Y113 H、H139 R多态性与COPD的相关性及其与氧化应激指标MDA、GSH、GPx和气流阻塞的关系进行了研究。患者由GST 1的等位基因105 V、114 V和mEPHX的等位基因113 H、139 H过度代表（chi（2）= 10.63，p = 0.001，chi（2）= 13.92，p < 0.001，chi（2）= 213.02，p <0.001和chi（2）=4.48，p=0.034，105 V-114 V和113 H-139 H的单倍型（χ 2 = 14.58，p
The genetic susceptibility to COPD might depend on variations in detoxification enzymes that activate and detoxify cigarette smoke products, which otherwise generate oxidative stress causing pathogenesis. In a case-control study of 202 COPD patients and 136 normals, we examined the association of polymorphisms 1105V, Al 14V of GSTP1 and Y113H, H139R of mEPHX individually or in combination with disease and their contribution to oxidative stress markers such as MDA, GSH, GPx and airflow obstruction. Patients were over-represented by the alleles 105V, 114V of GSTP1 and 113H, 139H of mEPHX (chi(2) = 10.63, p = 0.001, chi(2) = 13.92, p < 0.001, chi(2) = 213.02, p < 0.00 1 and chi(2) =4.48, p=0.034, respectively) and the haplotypes of same alleles i.e. 105V-114V and 113H-139H (chi(2) 14.58, p