Epstein-Barr virus associated gastric carcinoma: a report from Iran in the last four decades
Epstein-Barr virus associated gastric carcinoma: a report from Iran in the last four decades
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DOI：
10.1186/1746-1596-2-25
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Akiba, Suminori
中科院分区：
文献类型：
--
作者：
Abdirad, Afshin;Ghaderi-Sohi, Siavash;Akiba, Suminori
背景资料：EB病毒与人类多种恶性肿瘤有关，其中胃癌是世界上最重要的恶性肿瘤之一。有没有关于EBV在胃腺癌中的存在的研究在Irana.Methods：我们研究了EBV在273福尔马林固定石蜡包埋的胃癌病例从癌症研究所的德黑兰大学，从1969年至2004年的存在。进行EBV编码的小RNA-1（EBER-1）的原位杂交。结果：共检出EB病毒阳性9例（3%; 95%CI = 1-5%）。性别差异无统计学意义。弥漫型的EBV-GC比例高于肠型（OR = 0.08，95% CI = 0.002-0.64）。EBV-GC病例与年龄、部位、浸润无关。9例EBV-GC病例中有6例出生于1928年至1930年期间。9例均为A型。8例中6例为原型F。“i”型8例，I型1例。XhoI+和XhoI-多态性分别占6和3的cases.Conclusion：我们的研究是第一次描述的频率EBV-GC在伊朗和中东，突出了一个非常低的患病率与特定的临床病理特征。EBV-GC在一个固定时期的出生年份占优势，表明儿童早期的EBV感染或其他事件可能与以后生活中EBV-GC的发展有关。“i”型和XhoI+病例的优势与亚洲的其他研究相矛盾，与拉丁美洲国家报告的情况相似。
Background: Epstein-Barr virus has been proved to be associated with many of the human malignancy including gastric carcinoma, one of the most important human malignancies in the world. There has been no study about the presence of EBV in gastric adenocarcinoma in Iran.Methods: We examined the presence of EBV in 273 formalin fixed paraffin-embedded cases of gastric carcinoma from Cancer institute of Tehran University, from 1969 to 2004. In situ hybridization of EBV-encoded small RNA-1 (EBER-1) was conducted. The strain of positive cases was examined by means of polymerase chain reaction and/or restriction fragment length polymorphism analysis.Results: We found 9 (3%; 95% CI = 1-5%) EBV positive cases. The gender difference was not statisticaly significant. The proportion of EBV-GC cases in diffuse type was higher than intestinal type (OR = 0.08; 95% CI = 0.002-0.64). EBV-GC cases had no relation with age, location and invasion. Six out of 9 EBV-GC cases were born during the period between 1928 and 1930. All 9 cases were Type A. Prototype F was seen in 6 out of 8 cases. Type "i" was found in 8 cases and type I in 1 case. XhoI+ and XhoI- polymorphism accounted 6 and 3 of the cases, respectively.Conclusion: Our study is the first to describe the frequency of EBV-GC in Iran and the Middle East, highlighting a very low prevalence with specific clinicopathologic features. The predominance of EBV-GC birth year in a fixed period, suggests that EBV infection or other events at early childhood may be related to the development of EBV-GC later in the life. The predominance of the type "i" and XhoI+ cases are contradictory to other studies in Asia and is similar to what is reported from Latin American countries.