CONDITIONED-RESPONSES TO COCAINE-RELATED STIMULI IN COCAINE ABUSE PATIENTS
CONDITIONED-RESPONSES TO COCAINE-RELATED STIMULI IN COCAINE ABUSE PATIENTS
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DOI：
10.1007/bf02245266
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发表时间：
1992-06-01
影响因子：
3.4
通讯作者：
OBRIEN, CP
中科院分区：
文献类型：
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作者：
EHRMAN, RN;ROBBINS, SJ;OBRIEN, CP
受试者的自由基和吸烟可卡因的历史，但没有阿片类药物注射的历史暴露于三组刺激。他们在一次会议中接受可卡因相关的刺激，在第二次会议中接受阿片类药物相关的刺激，第三次接受非药物刺激。与阿片类药物和非药物线索相比，可卡因相关事件导致皮肤温度和皮肤电阻可靠降低，心率可靠增加，自我报告的可卡因渴望和自我报告的可卡因戒断。此外，有可卡因或阿片类药物使用史的对照组受试者没有表现出这种差异反应。这些结果表明，可卡因相关的刺激引起巴甫洛夫条件反射可卡因滥用患者。这些发现鼓励继续努力开发基于条件反射原则的药物治疗策略。
Subjects with a history of free-basing and smoking cocaine but no history of opiate injections were exposed to three sets of stimuli. They received cocaine-related stimuli in one session, opiate-related stimuli in a second session, and non-drug stimuli on a third occasion. Compared to the opiate and non-drug cues, the cocaine-related events caused reliable decreases in skin temperature and skin resistance, and reliable increases in heart rate, self-reported cocaine craving, and self-reported cocaine withdrawal. Furthermore, control subjects tacking a history of cocaine or opiate use failed to show such differential responding. These results suggest that cocaine-related stimuli evoke Pavlovian conditioned responses in cocaine abuse patients. Such findings encourage continuing efforts to develop drug treatment strategies based on conditioning principles.