GENETIC-CONTROL OF PROGRAMMED CELL-DEATH IN THE NEMATODE C-ELEGANS
GENETIC-CONTROL OF PROGRAMMED CELL-DEATH IN THE NEMATODE C-ELEGANS
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DOI：
10.1016/0092-8674(86)90004-8
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发表时间：
1986-03-28
期刊：
影响因子：
64.5
通讯作者：
HORVITZ, HR
中科院分区：
文献类型：
--
作者：
ELLIS, HM;HORVITZ, HR
ced-3和ced-4基因的野生型功能是秀丽隐杆线虫程序性细胞死亡启动所必需的。ced-3或ced-4功能的减少或丧失导致通常死亡的细胞命运的转变;在ced-3或ced-4突变体中，这些细胞反而存活并分化，采用野生型中与其他细胞相关的命运。ced-3和ced-4突变体在形态和行为上看起来非常正常，表明程序性细胞死亡不是线虫发育的重要方面。ced-3和ced-4基因定义了程序性细胞死亡发育途径的第一个已知步骤，表明这些基因可能参与决定哪些细胞在C. elegans发育
The wild-type functions of the genes ced-3 and ced-4 are required for the initiation of programmed cell deaths in the nematode Caenorhabditis elegans. The reduction or loss of ced-3 or ced-4 function results in a transformation in the fates of cells that normally die; in ced-3 or ced-4 mutants, such cells instead survive and differentiate, adopting fates that in the wild type are associated with other cells. ced-3 and ced-4 mutants appear grossly normal in morphology and behavior, indicating that programmed cell death is not an essential aspect of nematode development. The genes ced-3 and ced-4 define the first known step of a developmental pathway for programmed cell death, suggesting that these genes may be involved in determining which cells die during C. elegans development.