PIPE-CLIP: a comprehensive online tool for CLIP-seq data analysis.
PIPE-CLIP: a comprehensive online tool for CLIP-seq data analysis.
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DOI:
10.1186/gb-2014-15-1-r18
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发表时间:
2014-01-22
期刊:
影响因子:
12.3
通讯作者:
Xie Y
中科院分区:
文献类型:
--
作者:
Chen B;Yun J;Kim MS;Mendell JT;Xie Y
CLIP-seq is widely used to study genome-wide interactions between RNA-binding proteins and RNAs. However, there are few tools available to analyze CLIP-seq data, thus creating a bottleneck to the implementation of this methodology. Here, we present PIPE-CLIP, a Galaxy framework-based comprehensive online pipeline for reliable analysis of data generated by three types of CLIP-seq protocol: HITS-CLIP, PAR-CLIP and iCLIP. PIPE-CLIP provides both data processing and statistical analysis to determine candidate cross-linking regions, which are comparable to those regions identified from the original studies or using existing computational tools. PIPE-CLIP is available at http://pipeclip.qbrc.org/.
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影响因子:
4.4
作者:
Chou CH;Lin FM;Chou MT;Hsu SD;Chang TH;Weng SL;Shrestha S;Hsiao CC;Hung JH;Huang HD
通讯作者:
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14.9
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5.3
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Buckanovich, RJ;Darnell, RB
通讯作者:
Darnell, RB