Singlet oxygen generation using iodinated squaraine and squaraine-rotaxane dyes
Singlet oxygen generation using iodinated squaraine and squaraine-rotaxane dyes
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DOI：
10.1039/b616224j
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Smith, Bradley D.
中科院分区：
文献类型：
--
作者：
Arunkumar, Easwaran;Sudeep, Pallikkara K.;Smith, Bradley D.
The goal of this study was to assess the ability of squaraine-rotaxanes to generate singlet oxygen for potential application in photodynamic therapy (PDT). Specifically, we compare the aggregation and photophysical properties of an iodinated squaraine dye and an iodinated squaraine-rotaxane. Even under strongly aggregating conditions, the absorption spectra of both remain relatively sharp. An X-ray crystal structure of the iodinated squaraine dye shows that it adopts perpendicular, end-to-face orientations in the solid state. Singlet oxygen generation efficiency was measured by trapping with 1,3-diphenylisobenzofuran. The triplet state of the rotaxane was characterized using laser. ash photolysis. The results of this study suggest that heavily halogenated squaraine-rotaxanes have potential as singlet oxygen photosensitizers for PDT.
