LEVODOPA PHARMACOKINETICS AND PHARMACODYNAMICS IN FLUCTUATING PARKINSONIAN-PATIENTS
LEVODOPA PHARMACOKINETICS AND PHARMACODYNAMICS IN FLUCTUATING PARKINSONIAN-PATIENTS
复制标题
DOI：
10.1212/wnl.36.6.739
复制
发表时间：
1986-06-01
期刊：
影响因子：
9.9
通讯作者：
WOODWARD, WR
中科院分区：
文献类型：
--
作者：
NUTT, JG;WOODWARD, WR
我们研究了23例帕金森病患者的左旋多巴静脉输注速率、血浆浓度和临床反应，这些患者对药物的反应存在波动。左旋多巴与卡比多巴合用时，左旋多巴输注速率与血药浓度呈线性关系。左旋多巴的最小治疗有效血浆浓度范围为3至12 nmol/ml。临床应答的持续时间（而非幅度）与血浆浓度呈线性相关。临床反应滞后于血浆左旋多巴的升降。没有证据表明左旋多巴的特异质药代动力学或药效学反应可以解释波动的反应。
We investigated levodopa intravenous infusion rates, plasma concentrations, and clinical responses in 23 parkinsonian patients with a fluctuating response to the drug. There was a linear relationship between rate of levodopa infusion and plasma concentration when carbidopa was coadministered. Minimum-therapeutically effective plasma concentrations of levodopa ranged from 3 to 12 nmol/ml. The duration, but not the magnitude, of clinical response was linearly related to plasma concentrations. The clinical response lagged behind the rise and fall of plasma levodopa. There was no evidence of idiosyncratic pharmacokinetic or pharmacodynamic responses to levodopa to explain the fluctuating response.