Increased histamine release and granulocytes within the thalamus of a rat model of Wernicke's encephalopathy
Increased histamine release and granulocytes within the thalamus of a rat model of Wernicke's encephalopathy
复制标题
DOI：
10.1016/s0006-8993(99)02309-4
复制
发表时间：
2000-03
期刊：
影响因子：
2.9
通讯作者：
R. McRee;Melissa Terry-Ferguson;P. Langlais;Y. Chen;J. Nalwalk;F. Blumenstock;L. Hough
中科院分区：
文献类型：
--
作者：
R. McRee;Melissa Terry-Ferguson;P. Langlais;Y. Chen;J. Nalwalk;F. Blumenstock;L. Hough
本研究以吡硫胺硫胺缺乏(PTD)WerNicke‘s脑病(WE)大鼠模型为模型，研究了组胺释放和粒细胞活性增加在坏死性病变发生前的血管变化中的可能作用。PTD治疗第9天，外侧丘脑和第10天内侧丘脑的组胺释放和粒细胞数量增加，这段时间硫胺素缺乏与该脑区的血管周围水肿有关。在海马区，组胺释放在第9天显著增加，在第10-12天下降到对照水平，在第12-14天显著升高。这些观察表明，神经末梢释放组胺和粒细胞释放组胺和其他血管活性物质可能是硫胺素缺乏导致丘脑内血管破裂和血管周围水肿的原因。
The current study examined the possible role of increased histamine release and granulocyte activity in the vascular changes that precede the onset of necrotic lesions with the thalamus of the pyrithiamine-induced thiamine deficiency (PTD) rat model of Wernicke's encephalopathy (WE). An increase in histamine release and the number of granulocytes was observed in lateral thalamus on day 9 and in medial thalamus on day 10 of PTD treatment, a duration of thiamine deficiency associated with perivascular edema in this brain region. Within the hippocampus, histamine release was significantly increased on day 9, declined to control levels on days 10–12, and was significantly elevated on days 12–14. No granulocytes were observed in hippocampus of either PTD or control rats. These observations suggest that the release of histamine from nerve terminals and histamine and other vasoactive substances from granulocytes may be responsible for thiamine deficiency-induced vascular breakdown and perivascular edema within thalamus.