Alcohols stimulate γ-aminobutyric acid receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency
Alcohols stimulate γ-aminobutyric acid receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency
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酒精刺激脑囊泡中γ-氨基丁酸受体介导的氯化物吸收：与中毒效力的相关性
DOI：
10.1016/0006-8993(88)90943-2
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
S. Paul
中科院分区：
文献类型：
--
作者：
P. Suzdak;R. D. Schwartz;P. Skolnick;S. Paul
A series of short-chain alcohols, including ethanol, were examined for their abilities to stimulate γ-aminobutyric acid (GABA) receptor-mediated chloride uptake into isolated brain vesicles. All of the alcohols tested stimulated36chloride uptake, at concentrations that occur during acute intoxication, and their potencies in stimulating GABA receptor-mediated chloride uptake were highly correlated with both their intoxication potencies in rats (r= 0.96;P< 0.0001) and their membrane/buffer partition coefficients (r= 0.91;P< 0.0005). Thus, the activity of alcohols at the GABA receptor-coupled chloride ion channel appears to be related to their ability to enter hydrophobic regions of the neuronal membrane. These data suggest that the anxiolytic, sedative/hypnotic and intoxicating properties of ethanol may, in part, in mediated via an action at central GABA receptors.
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影响因子：
3.6
作者：
Davis,WC;Ticku,MK
通讯作者：
Ticku,MK
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DOI：
--
发表时间：
1981
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Lyon,RC;McComb,JA;Schreurs,J;Goldstein,DB
通讯作者：
Goldstein,DB
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DOI：
10.1111/j.1530-0277.1984.tb05700.x
发表时间：
1984
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Wilsnack,SC;Klassen,AD;Wilsnack,RW
通讯作者：
Wilsnack,RW
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DOI：
--
发表时间：
1985
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Harris,RA;Bruno,P
通讯作者：
Bruno,P