Accelerated Segmented Diffusion-Weighted Prostate Imaging for Higher Resolution, Higher Geometric Fidelity, and Multi-b Perfusion Estimation.
Accelerated Segmented Diffusion-Weighted Prostate Imaging for Higher Resolution, Higher Geometric Fidelity, and Multi-b Perfusion Estimation.
复制标题
加速分段扩散加权前列腺成像，可实现更高的分辨率、更高的几何保真度和多 b 灌注估计。
DOI：
10.1097/rli.0000000000000536
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发表时间：
2019
影响因子：
6.7
通讯作者：
Maier,StephanE
中科院分区：
文献类型：
--
作者：
AksitCiris,Pelin;Chiou,Jr-YuanGeorge;Glazer,DanielI;Chao,Tzu-Cheng;Tempany-Afdhal,ClareM;Madore,Bruno;Maier,StephanE
目的本研究的目的是提高前列腺多b扩散加权磁共振成像的几何保真度和空间分辨率。材料和方法开发了加速分段扩散成像序列，并在25名接受前列腺多参数磁共振成像检查的患者中进行了评估。使用直肠内线圈获得缩小的视野。采样扩散权重或 b 因子的数量增加，以便能够根据体素内不相干运动 (IVIM) 模型估计组织灌注。将使用所提出的分段方法测量的表观扩散系数与传统单次平面回波成像（EPI）获得的表观扩散系数进行比较。结果与单次EPI相比，分段方法的采集速度更快，空间分辨率提高了2倍，几何保真度提高了3倍以上。使用新序列测量的表观扩散系数值与传统扫描获得的值非常一致（b max= 500 s/mm 2 时，R 2= 0.91；b max= 1400 s/mm 2 时，R 2= 0.89）。正常周边区的 IVIM 灌注分数为 4.0%±2.7%，正常过渡区为 6.6%±3.6%，疑似肿瘤病变为 4.4%±2.9%。结论所提出的加速分段前列腺扩散成像序列在空间分辨率和几何保真度方面均取得了改进，同时对 IVIM 灌注进行了量化。
PurposeThe aim of this study was to improve the geometric fidelity and spatial resolution of multi-b diffusion-weighted magnetic resonance imaging of the prostate.Materials and MethodsAn accelerated segmented diffusion imaging sequence was developed and evaluated in 25 patients undergoing multiparametric magnetic resonance imaging examinations of the prostate. A reduced field of view was acquired using an endorectal coil. The number of sampled diffusion weightings, or b-factors, was increased to allow estimation of tissue perfusion based on the intravoxel incoherent motion (IVIM) model. Apparent diffusion coefficients measured with the proposed segmented method were compared with those obtained with conventional single-shot echo-planar imaging (EPI).ResultsCompared with single-shot EPI, the segmented method resulted in faster acquisition with 2-fold improvement in spatial resolution and a greater than 3-fold improvement in geometric fidelity. Apparent diffusion coefficient values measured with the novel sequence demonstrated excellent agreement with those obtained from the conventional scan (R 2= 0.91 for b max= 500 s/mm 2 and R 2= 0.89 for b max= 1400 s/mm 2). The IVIM perfusion fraction was 4.0%±2.7% for normal peripheral zone, 6.6%±3.6% for normal transition zone, and 4.4%±2.9% for suspected tumor lesions.ConclusionsThe proposed accelerated segmented prostate diffusion imaging sequence achieved improvements in both spatial resolution and geometric fidelity, along with concurrent quantification of IVIM perfusion.