Mitochondria in Ischemic Stroke: New Insight and Implications.
Mitochondria in Ischemic Stroke: New Insight and Implications.
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线粒体在缺血性中风中的作用：新的见解和意义
DOI：
10.14336/ad.2017.1126
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发表时间：
2018-10
影响因子：
7.4
通讯作者：
Hu Q
中科院分区：
文献类型：
--
作者：
Liu F;Lu J;Manaenko A;Tang J;Hu Q
中风是全世界成年人死亡和残疾的主要原因。线粒体功能障碍被认为是缺血/再灌注（I/R）诱导的神经元死亡的标志之一。维持线粒体的功能对促进神经元存活和神经功能改善至关重要。本文就线粒体在脑I/R损伤病理过程中的作用作一综述。特别是，我们强调负责线粒体质量控制的最关键的机制，以及最近在急性卒中中线粒体转移的发现。我们强调了线粒体作为中风治疗靶点的潜力，并为临床策略提供了有价值的见解。
Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies.