CARDIOVASCULAR-RESPONSES TO EXERCISE - EFFECTS OF AGING AND EXERCISE TRAINING IN HEALTHY-MEN
CARDIOVASCULAR-RESPONSES TO EXERCISE - EFFECTS OF AGING AND EXERCISE TRAINING IN HEALTHY-MEN
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DOI：
10.1161/01.cir.89.4.1648
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发表时间：
1994-04-01
期刊：
影响因子：
37.8
通讯作者：
ABRASS, IB
中科院分区：
文献类型：
--
作者：
STRATTON, JR;LEVY, WC;ABRASS, IB
心脏老化改变了许多对运动应激的急性反应，但慢性运动（训练）能在多大程度上改变或改善人类衰老的影响在很大程度上是未知的。方法和结果对13名老年人（年龄60 ~ 82岁）和11名年轻人（年龄24 ~ 32岁）经过严格筛选的健康男性进行6个月耐力训练前后的心血管反应进行了放射性核素脑室造影评估（从200公里每分钟开始，每3分钟增加200公里每分钟直到精疲力竭）。采用重复测量方差分析检验显著性。在运动期间，老年组心率的增加幅度较小（老年人+105%，年轻人+166%），平均血压的增加幅度较大（老年人+35%，年轻人+22%），射血分数的增加较小（老年人+3，年轻人+11）和射血峰值率的增加较小（老年人+62%，年轻人+119%），舒张末期容积指数的增加较大（老年人+8%，年轻人-10%），收缩末期容积指数的下降较小（老年人-0%，年轻人-32%）。心脏指数的增加幅度较小（老年人+135%，年轻人+189%）
Background Cardiac aging alters many of the acute responses to exercise stress, but the extent to which chronic exercise tie, training) can alter or improve the effects of aging in humans is largely unknown.Methods and Results Cardiovascular responses to graded supine exercise stress (beginning at 200 kpm and increasing by 200 kpm every 3 minutes till exhaustion) were assessed using radionuclide ventriculography in 13 older (age, 60 to 82 years) and 11 young (age, 24 to 32 years) rigorously screened healthy men before and after 6 months of endurance training. Repeated-measures ANOVA was used to test significance. During exercise, the old group had a lesser increase in heart rate (+105% old versus +166% young), a greater increase in mean blood pressure (+35% old versus +22% young), lesser increases in ejection fraction (+3 ejection fraction units old versus +11 units young) and peak ejection rate (+62% old versus +119% young), a greater increase in end-diastolic volume index (+8% old versus -10% young), a lesser fall in end-systolic volume index (-0% old versus -32% young), and a lesser increase in cardiac index (+135% old versus +189% young) (all P