Constitutively high-level expression of TGFβ isoforms in cord blood and its relationship to perinatal findings.
Constitutively high-level expression of TGFβ isoforms in cord blood and its relationship to perinatal findings.
复制标题
脐带血中 TGFβ 同工型的组成性高水平表达及其与围产期发现的关系。
DOI：
10.1016/j.cyto.2015.01.024
复制
发表时间：
2015
期刊：
影响因子：
3.8
通讯作者：
Kono Y
中科院分区：
文献类型：
--
作者：
Takahashi N;Takahashi K;Kobayashi M;Yada Y;Koike Y;Kono Y
背景：脐带血中转化生长因子β亚型的临床意义尚不清楚。结果脐带血中转化生长因子β1和转化生长因子β2亚型水平明显高于其他细胞因子，平均水平分别为44、180和1871npg/m L。3种转化生长因子β亚型水平与出生体重显著相关，转化生长因子β1和转化生长因子β3水平与胎龄相关。转化生长因子β-1和β-2亚型水平与其他细胞因子水平无相关性。转化生长因子β-1和转化生长因子β-2在男婴中显著升高，在胎儿生长受限患儿中显著降低。结论转化生长因子β-1和转化生长因子β-2在早产儿的生理和病理状态中起重要作用。转化生长因子β亚型水平似乎独立于其他细胞因子调节，并且似乎不受胎儿期炎症的影响。转化生长因子β-3在脐血中的作用及转化生长因子β亚型在出生后的时间变化有待进一步研究。
BackgroundThe clinical significance of TGFβ isoforms in cord blood is not well understood.MethodsWe obtained cord blood samples from 37 term infants and 85 preterm infants who were born in several clinical settings. The serum levels of 3 TGFβ isoforms and of the other 17 cytokines in cord blood were investigated using cytometric bead array technology.ResultsVery high levels of TGFβ1 and TGFβ2 isoforms compared to the level of other cytokines were found; mean levels were 44,180 and 1871 pg/mL, respectively. The levels of all 3 isoforms of TGFβ were significantly correlated with birth weight, and the levels of TGFβ1 and TGFβ3 were correlated with gestational age. The levels of TGFβ1 and β2 isoforms were strongly correlated with each other, but not with levels of other cytokines. The levels of TGFβ1 and TGFβ2 were significantly higher in male infants and significantly lower in infants with fetal growth restriction. The prevalence of chronic lung disease was related to a low level of TGFβ1, and that of patent ductus arteriosus was related to a high level of TGFβ1 in preterm infants.ConclusionsTGFβ1 and TGFβ2 appeared to play a significant role in physiological and pathological conditions in the fetus. TGFβ isoform levels appear to be regulated independently of those of other cytokines and do not appear to be influenced by inflammation in the fetal period. The role of TGFβ3 in cord blood and the postnatal chronological changes of the TGFβ isoforms should be investigated in the future.