Long-term outcomes of adolescents with juvenile-onset fibromyalgia into adulthood and impact of depressive symptoms on functioning over time.
Long-term outcomes of adolescents with juvenile-onset fibromyalgia into adulthood and impact of depressive symptoms on functioning over time.
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DOI：
10.1097/j.pain.0000000000001415
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发表时间：
2019-03
期刊：
影响因子：
7.4
通讯作者：
Lovell DJ
中科院分区：
文献类型：
--
作者：
Kashikar-Zuck S;Cunningham N;Peugh J;Black WR;Nelson S;Lynch-Jordan AM;Pfeiffer M;Tran ST;Ting TV;Arnold LM;Carle A;Noll J;Powers SW;Lovell DJ
Juvenile-onset fibromyalgia (JFM) is typically diagnosed in adolescence and characterized by widespread pain and marked functional impairment. The long-term impact of JFM into adulthood is poorly understood. The objectives of this study were to describe physical and psychosocial outcomes of youth diagnosed with JFM in early adulthood (~ 8-year follow-up), examine longitudinal trajectories of pain and depressive symptoms from adolescence to young adulthood, and examine the impact of pain and depressive symptoms on physical functioning over time. Participants were 97 youth with JFM enrolled in a prospective longitudinal study in which pain symptoms, physical and psychosocial functioning were assessed at four time points over approximately eight years. At the Time 4 follow-up (Mage = 24.2 years), the majority continued to suffer from pain and impairment in physical, social, and psychological domains. However, trajectories of pain and emotional symptoms showed varying patterns. Longitudinal analysis using growth mixture modeling revealed two pain trajectories (Steady Improvement and Rapid Rebounding Improvement); whereas depressive symptoms followed three distinct trajectories (Low-Stable, Improving, and Worsening). Membership in the Worsening Depressive symptoms group was associated with poorer physical functioning over time (p < .001) compared to the Low-Stable and Improving groups. This study offers evidence that while JFM symptoms persist for most individuals, pain severity tends to decrease over time. However, depressive symptoms follow distinct trajectories that indicate subgroups of JFM. In particular, JFM patients with worsening depressive symptoms showed decreasing physical functioning and may require more intensive and consistent intervention to prevent long-term disability. Longitudinal trajectory analyses showed decreasing pain over time in juvenile-onset fibromyalgia. A worsening depressive symptom trajectory was associated with the poorest outcomes in adulthood.
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DOI：
10.1186/s12969-015-0013-0
发表时间：
2015-05-24
期刊：
Pediatric rheumatology online journal
影响因子：
--
作者：
Jensen PT;Karnes J;Jones K;Lehman A;Rennebohm R;Higgins GC;Spencer CH;Ardoin SP
通讯作者：
Ardoin SP
影响因子：
4.7
作者：
Kashikar-Zuck, Susmita;Flowers, Stacy R.;Schikler, Kenneth N.
通讯作者：
Schikler, Kenneth N.
影响因子：
3.4
作者：
Epstein, SA;Kay, G;Zisook, S
通讯作者：
Zisook, S
影响因子：
2
作者：
Celeux, G;Soromenho, G
通讯作者：
Soromenho, G
DOI：
10.3899/jrheum.141369
发表时间：
2015-12
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Cunningham NR;Tran ST;Lynch-Jordan AM;Ting TV;Sil S;Strotman D;Noll JG;Powers SW;Arnold LM;Kashikar-Zuck S
通讯作者：
Kashikar-Zuck S