Diagnostic and prognostic relevance of autoantibodies in uranium miners
Diagnostic and prognostic relevance of autoantibodies in uranium miners
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DOI：
10.1159/000024426
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发表时间：
2000-09-01
影响因子：
2.8
通讯作者：
Mehlhorn, J
中科院分区：
文献类型：
--
作者：
Conrad, K;Mehlhorn, J
接触硅尘的铀矿工人患系统性硬化症（SSc）和系统性红斑狼疮（SLE）的风险较高。对1976名前铀矿工人的血清进行了结缔组织病典型的自身抗体分析。其中一些抗体（抗着丝粒，拓扑异构酶I，核仁，双链DNA，Ro/SSA，La-SSB和U1-RNP抗体）的频率显着高于性别和年龄匹配的对照组，并与暴露的强度以及SSc或SLE的临床症状。研究还表明，Ssc相关自身抗体可作为疾病发展的早期指标。硅尘相关和特发性SLE/SSc之间的自身抗体产生的一些差异进行了观察，可能是由环境因素在铀矿工人的人口。版权所有（C）2000 S.作者声明：Karger AG.
Uranium miners exposed to silica dust have a higher risk of developing systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). Sera of 1976 former uranium miners were analysed for autoantibodies typical of connective tissue disease. The frequency of some of these antibodies (anti-centromere, -topoisomerase I, -nucleolar, -dsDNA, -Ro/SSA, -La-SSB and U1-RNP antibodies) was significantly higher compared to a gender- and age-matched control group and was associated with the intensity of exposure as well as with clinical symptoms of SSc or SLE. It was also shown that SSc-associated autoantibodies may serve as an early indicator of disease development. Some differences in the autoantibody production between silica-dust-associated and idiopathic SLE/SSc were observed that might be caused by environmental factors in the population of uranium miners. Copyright(C) 2000 S. Karger AG.Basel.