Natural type I interferon-producing cells as a link between innate and adaptive immunity
Natural type I interferon-producing cells as a link between innate and adaptive immunity
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DOI：
10.1016/s0198-8859(02)00751-6
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发表时间：
2002-12-01
期刊：
影响因子：
2.7
通讯作者：
Liu, YJ
中科院分区：
文献类型：
--
作者：
Kadowaki, N;Liu, YJ
I型干扰素(IFN)在病原体入侵时迅速产生，并激活先天和获得性免疫系统中广泛的效应细胞。LIN(-)CD4(+)CD11c(-)浆细胞样树突状细胞前体(浆细胞样前DC)在病毒和CpG DNA的作用下产生大量的I型IFN，因此与前面描述的但尚未完全定义的自然I型干扰素产生细胞(IPC)相对应。浆细胞样前DC强烈表达Toll样受体(TLR7)和TLR9，而单核细胞主要表达TLR1、2、4、5和8，提示这两种DC前体识别不同的微生物分子，可能是通过不同的进化途径发展起来的。三种不同的刺激，CpG DNA加CD40配体，白介素3(IL-3)，和单纯疱疹病毒，刺激浆细胞样前DC分化为DC，从而分别诱导不同类型的T辅助细胞，即Th1，Th2，以及产生干扰素-γ和IL-10的T细胞。浆细胞样前树突状细胞的显著多样性使它们有别于免疫系统中仅具有有限功能的其他细胞类型，并提示这些细胞可能在整合各种免疫反应的先天和适应性方面发挥关键作用。
Type I interferons (IFNs) are promptly produced upon invasion of pathogens, and activate a broad range of effector cells in the innate and adaptive immune system. Lin(-)CD4(+)CD11c(-) plasmacytoid dendritic cell precursors (plasmacytoid pre-DCs) produce enormous amounts of type I IFNs in response to viruses and CpG DNA, thus corresponding to the previously described but not fully defined natural type I IFN-producing cells (IPCs). Plasmacytoid pre-DCs strongly express toll-like receptor (TLR) 7 and TLR9, in contrast to monocytes, which mainly express TLR1, 2, 4, 5, and 8, suggesting that these two DC precursors recognize different microbial molecules and that they may have developed through different evolutionary trails. Three different stimuli, CpG DNA plus CD40 ligand, interleukin-3 (IL-3), and herpes simplex virus, stimulate plasmacytoid pre-DCs to differentiate into DCs that induce distinct types of T helper cells, i.e., Th1, Th2, and IFN-gamma- and IL-10-producing T cells, respectively. The remarkable versatility of plasmacytoid pre-DCs distinguishes them from other cell types in the immune system that have only limited functions, and suggests that these cells may play a key role in integrating the innate and adaptive aspects of various immune responses.