CORRELATION OF DIRECTLY OBSERVED RESPONSES OF MESENTERIC VESSELS OF RAT TO NERVE-STIMULATION AND NORADRENALINE WITH DISTRIBUTION OF ADRENERGIC NERVES
CORRELATION OF DIRECTLY OBSERVED RESPONSES OF MESENTERIC VESSELS OF RAT TO NERVE-STIMULATION AND NORADRENALINE WITH DISTRIBUTION OF ADRENERGIC NERVES
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DOI：
10.1113/jphysiol.1974.sp010556
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发表时间：
1974-01-01
影响因子：
5.5
通讯作者：
MARSHALL, JM
中科院分区：
文献类型：
--
作者：
FURNESS, JB;MARSHALL, JM
1.通过在显微镜下直接观察来检查神经刺激和局部应用去甲肾上腺素对麻醉大鼠肠系膜的动脉、毛细血管和静脉的影响。采用荧光组织化学方法研究肾上腺素能神经在肠系膜血管的分布情况。 2．主动脉、小动脉和终末小动脉均由肾上腺素能纤维网络支配，并且它们均响应血管旁神经和外源性去甲肾上腺素的刺激而收缩。较小的毛细血管前小动脉很少有肾上腺素能纤维；这些血管对神经刺激没有反应，尽管它们被低至 10−10g/ml 浓度的去甲肾上腺素收缩。3。毛细血管对神经刺激或去甲肾上腺素没有反应。所有静脉均被去甲肾上腺素收缩，但只有内径大于约30μm的静脉对神经刺激有反应。4．当刺激频率大于 4 Hz 时，流经微脉管系统的血液通常会停止，尽管这些血管从未完全闭合。在主动脉中观察到的最大收缩通常在对照内径的50%到70%之间，在小动脉和终末小动脉中观察到的最大收缩在对照内径的40%到65%之间。5．结论是，在交感神经刺激期间和局部应用去甲肾上腺素之后，肠系膜脉管系统的主动脉和小动脉对于控制通过该血管床的血流非常重要，并且毛细血管前小动脉是决定静息条件下通过毛细血管床的血流速率的重要血管。
1. The effects of nerve stimulation and of the topical application of noradrenaline on arteries, capillaries and veins of the mesentery of the anaesthetized rat were examined by direct observation under a microscope. The distribution of adrenergic nerves to the vessels of the mesentery was studied using the fluorescence histochemical method.2. Principal arteries, small arteries and terminal arterioles were all innervated by a network of adrenergic fibres and they all constricted in response to the stimulation of paravascular nerves and to exogenous noradrenaline. Few adrenergic fibres accompanied the smaller, precapillary arterioles; these vessels did not respond to nerve stimulation, although they were constricted by concentrations of noradrenaline as low as 10−10g/ml.3. The capillaries did not respond to nerve stimulation or to applied noradrenaline. All veins were constricted by noradrenaline, but only those veins greater than about 30 μm in internal diameter responded to nerve stimulation.4. At stimulus frequencies greater than 4 Hz the flow of blood through the microvasculature usually ceased, although there was never complete closure of these vessels. The maximum constriction observed in principal arteries was usually between 50 and 70% of the control internal diameter, and in small arteries and terminal arterioles was between 40 and 65% of the control internal diameter.5. It is concluded that the principal arteries and small arteries of the mesenteric vasculature are important in the control of blood flow through this vascular bed during sympathetic stimulation and following topical application of noradrenaline, and that the precapillary arterioles are important vessels determining the rate of blood flow through the capillary bed under resting conditions.