Understanding the control of acyl flux through the lipid metabolic network of plant oil biosynthesis
Understanding the control of acyl flux through the lipid metabolic network of plant oil biosynthesis
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DOI：
10.1016/j.bbalip.2016.03.021
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发表时间：
2016-09-01
影响因子：
4.8
通讯作者：
Bates, Philip D.
中科院分区：
文献类型：
--
作者：
Bates, Philip D.
植物油的生物合成涉及一个复杂的代谢网络，包括多个亚细胞室、平行的途径、循环和具有双重功能的途径，这些途径产生必需的膜脂和三酰甘油。现代分子生物学技术提供了通过生物工程改变植物油组成的工具，然而，除了极少数例外，三酰甘油的最终组成无法预测。油籽生物工程成功有限的一个原因是对如何通过各种脂肪酸修饰来控制脂肪酸的通量以及三酰甘油在脂类代谢网络中的组装途径了解不足。本文重点介绍了脂类代谢网络中酰基流动的机制，并着重指出了我们对种子油生物合成的理解中存在的不确定性。本文是由Kent D.Chapman和Ivo Feussner编辑的题为：植物脂肪生物学的特刊的一部分。(C)2016爱思唯尔B.V.保留所有权利。
Plant oil biosynthesis involves a complex metabolic network with multiple subcellular compartments, parallel pathways, cycles, and pathways that have a dual function to produce essential membrane lipids and triacylglycerol. Modern molecular biology techniques provide tools to alter plant oil compositions through bioengineering, however with few exceptions the final composition of triacylglycerol cannot be predicted. One reason for limited success in oilseed bioengineering is the inadequate understanding of how to control the flux of fatty acids through various fatty acid modification, and triacylglycerol assembly pathways of the lipid metabolic network. This review focuses on the mechanisms of acyl flux through the lipid metabolic network, and highlights where uncertainty resides in our understanding of seed oil biosynthesis. This article is part of a Special Issue entitled: Plant Lipid Biology edited by Kent D. Chapman and Ivo Feussner. (C) 2016 Elsevier B.V. All rights reserved.