Uptake and metabolism of thyroid hormones by the rat foetus in early pregnancy.
Uptake and metabolism of thyroid hormones by the rat foetus in early pregnancy.
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妊娠早期大鼠胎儿对甲状腺激素的吸收和代谢。
DOI：
10.1042/cs0670359
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发表时间：
1984
期刊：
影响因子：
6
通讯作者：
R. Ekins
中科院分区：
文献类型：
--
作者：
R. Woods;A. Sinha;R. Ekins
给怀孕大鼠注射微量[125I]甲状腺素[（125I]T4）或[125I]-三碘甲状腺原氨酸[（125I]T3）。分别于1和4 h后取出母体血液、脏器和胎儿，均质后加入三氯乙酸沉淀放射性标记的碘甲状腺原氨酸。注射[125I]甲状腺素1小时后，9-10日龄胎儿的放射性标签含量为相同重量血浆中的21%，而13-14日龄胎儿的放射性标签含量为0.6%。注射[125I]三碘甲状腺原氨酸一小时后，9-10日龄胎儿的放射性是同等重量血浆中的54%。当与组织蛋白有关时，9-10日龄胎儿的放射性标记碘甲状腺原氨酸含量与母体大脑、心脏或卵巢的含量相当。[125I]甲状腺素在9-10日龄胎儿胎盘单位的去碘量与母体肝脏的去碘量相等，但大于母体大脑和心脏的去碘量。由此可见，妊娠早期大鼠胎儿可摄入大量甲状腺素和三碘甲状腺原氨酸，但妊娠后期甲状腺素摄取可能很少。
Pregnant rats were injected with trace amounts of [125I]thyroxine [( 125I]T4) or [125I]-tri-iodothyronine [( 125I]T3). Maternal blood, organs and foetuses were removed 1 and 4 h later, homogenized and tri-chloroacetic acid added to precipitate radiolabelled iodothyronines. An hour after injecting [125I]thyroxine, 9-10 day old foetuses contained 21% of the radiolabel found in the same weight of plasma whereas by 13-14 days they contained 0.6%. An hour after injection of [125I]tri-iodothyronine, 9-10 day old foetuses contained 54% of the radioactivity present in the same weight of plasma. When related to tissue protein, the radiolabelled iodothyronine content in 9-10 day old foetuses was comparable with that in maternal brain, heart or ovary. De-iodination of [125I]thyroxine in 9-10 day old foetoplacental units was equal to that in maternal liver but greater than that in brain or heart. It is concluded that substantial amounts of thyroxine and tri-iodothyronine enter the rat foetus in early pregnancy but thyroxine uptake may be minimal in later pregnancy.