Compatibility between a rabies vaccine and a combined vaccine against canine distemper, adenovirosis, parvovirosis, parainfluenza virus and leptospirosis
Compatibility between a rabies vaccine and a combined vaccine against canine distemper, adenovirosis, parvovirosis, parainfluenza virus and leptospirosis
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DOI：
10.1016/j.vetimm.2018.11.001
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发表时间：
2018-11-01
影响因子：
1.8
通讯作者：
Guigal, P. M.
中科院分区：
文献类型：
--
作者：
Bouvet, J.;Cariou, C.;Guigal, P. M.
在许多情况下，兽医要求在接种犬瘟热、腺病毒、细小病毒、副流感病毒和钩端螺旋体病疫苗的同时，给狗接种狂犬病疫苗。这项研究的目的是评估在两个不同的地点注射多价疫苗和狂犬病疫苗之间的相容性。通过比较初级疫苗接种后一年内对病毒成分的血清学反应与单独或联合接种疫苗来评估缺乏干预。无论疫苗是单独接种还是同时接种，对所有被测成分的抗体反应都是相似的。值得注意的是，狂犬病疫苗在狗中诱导了非常强的保护性血清转换，无论它是否与联合疫苗一起接种。这有利于狂犬病疫苗的接种，而狂犬病疫苗是控制疾病的关键因素。
In many cicumstances, veterinarians are requiring to be able to administer rabies vaccine in dogs at the same time as vaccinating against canine distemper, adenovirus, parvovirus, parainfluenza virus and leptospirosis. The aim of this study was to assess the compatibility between a multivalent vaccine and a rabies vaccine when injected at two separate sites. Lack of interference was assessed by comparing serological response to viral components during one year following primary vaccination with vaccines administered alone or concomitantly. Antibody response to all tested components was comparable, irrespective of whether vaccines were administered individually or concurrently. Notably, the rabies vaccine induced very strong and protective seroconversion in dogs, whether it was administered concomitantly with the combo vaccine or not. This facilitates administration of rabies vaccine, which is a key factor for controlling the disease.