Ectopia cordis thoracalis with craniofacial defects resulting from early amnion rupture.
Ectopia cordis thoracalis with craniofacial defects resulting from early amnion rupture.
复制标题
胸心异位伴早期羊膜破裂导致的颅面缺损。
DOI：
10.1002/tera.1420320104
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Myhre,S
中科院分区：
文献类型：
--
作者：
VanAllen,MI;Myhre,S
一个33周妊娠的胎儿被评价为患有胸心异位、中线胸骨裂、额鼻发育不全、面中部裂和羊膜带。纤维带附着在心脏、面部和大脑的顶端。没有相关的肢体缺陷或脊柱侧凸。本例胎儿的发现和文献中的发现提示妊娠第三周急性羊膜破裂可能是导致这些缺陷的原因。组织带附着于心脏的机械性致畸作用可导致心脏异位。胸部、面部和脑部的变化提示压迫性坏死、形态发生不完全、羊膜撕裂和束缚以及压迫是这些缺陷的原因。羊膜破裂后发现一系列缺陷，异常取决于事件发生的时间。羊膜带性心脏异位的病因似乎与单纯性心脏异位不同。这表明心脏异位有几种不同的病因。
A 33‐week‐gestation fetus was evaluated as having ectopia cordis thoracalis, midline sternal cleft, frontonasal dysgenesis, a midfacial cleft, and amniotic bands. Fibrous bands were attached to the apex of the heart, face, and the brain. There were no associated limb defects or scoliosis. The findings in this fetus and those in the literature suggest that acute amnion rupture in the third week of gestation may be the cause of these defects. Mechanical teratogenesis by tissue bands adherent to the heart may lead to ectopia cordis. The changes seen in the thorax, face, and brain suggest pressure necrosis, incomplete morphogenesis, tearing and tethering by amnion, and compression as a cause for these defects. A spectrum of defects is found following amnion rupture with the abnormalities being dependent upon the timing of the event. Ectopia cordis with amniotic bands appears to have an etiology distinct from isolated ectopia cordis. This suggests several different etiologies for ectopia cordis.