The relation of circulating YKL-40 to levels and decline of lung function in adult life.
The relation of circulating YKL-40 to levels and decline of lung function in adult life.
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DOI：
10.1016/j.rmed.2013.07.013
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发表时间：
2013-12
影响因子：
4.3
通讯作者：
Martinez, Fernando D.
中科院分区：
文献类型：
--
作者：
Guerra, Stefano;Halonen, Marilyn;Sherrill, Duane L.;Venker, Claire;Spangenberg, Amber;Carsin, Anne-elie;Tares, Lluisa;Lavi, Iris;Barreiro, Esther;Martinez-Moratalla, Jesus;Urrutia, Isabel;Sunyer, Jordi;Anto, Josep M.;Martinez, Fernando D.
YKL-40 is a chitinase-like protein that, in cross-sectional clinical studies, has been associated with severe asthma and COPD in smokers. To determine the longitudinal relation of circulating YKL-40 to levels and lung function decline in the general population. We used longitudinal data from up to 12 surveys from the population-based TESAOD study which was conducted in Tucson, Arizona between 1972-1996. In cross-sectional analyses, we also used data from 3 Spanish centers of the multicenter ECRHS study (ECRHS-Sp). Serum YKL-40 was measured at baseline in TESAOD and in survey 2 in ECRHS-Sp using ELISAs. Multivariate linear regression was used to test associations of serum YKL-40 to concomitant lung function. In TESAOD, random coefficients models were used to test associations of serum YKL-40 to subsequent decline of lung function. Data on YKL-40 and lung function were available from 1088 TESAOD and 854 ECRHS-Sp adult participants (59% and 51% females; respectively). In adjusted multivariate meta-analyses, being in the highest YKL-40 quartile was associated cross-sectionally with significant deficits in FEV1 and FVC %predicted. In adjusted longitudinal analyses, TESAOD participants in the top YKL-40 quartile had an FEV1 decline that was 5 ml/yr (p=0.05) faster than subjects in the third quartile, 5 ml/yr (p=0.02) faster than subjects in the second quartile, and 10 ml/yr (p<0.001) faster than subjects in the lowest YKL-40 quartile. These longitudinal effects were particularly strong in smokers and absent in never smokers. After adjusting for covariates, as compared with the other three quartiles combined the top YKL-40 quartile was associated with a 9 ml/yr (p=0.001) faster FEV1 decline among smokers, while no significant effects were found among never smokers (2 ml/yr, p=0.35). Circulating YKL-40 is associated with levels and decline of lung function in the general population and may be a biomarker of susceptibility to the long-term effects of cigarette smoking.
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影响因子：
12.4
作者：
Anto, J. M.;Sunyer, J.;Burney, P.
通讯作者：
Burney, P.
影响因子：
4.6
作者：
Johansen, J. S.;Pedersen, A. N.;Bruunsgaard, H.
通讯作者：
Bruunsgaard, H.
影响因子：
9.3
作者：
Johansen, Julia S.;Bojesen, Stig E.;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.
影响因子：
5
作者：
LEBOWITZ, MD;KNUDSON, RJ;BURROWS, B
通讯作者：
BURROWS, B
DOI：
10.1084/jem.20081271
发表时间：
2009-05-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lee CG;Hartl D;Lee GR;Koller B;Matsuura H;Da Silva CA;Sohn MH;Cohn L;Homer RJ;Kozhich AA;Humbles A;Kearley J;Coyle A;Chupp G;Reed J;Flavell RA;Elias JA
通讯作者：
Elias JA