Amelioration of photic injury in rat retina by ascorbic acid: a histopathologic study.
Amelioration of photic injury in rat retina by ascorbic acid: a histopathologic study.
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发表时间：
1985-11
影响因子：
4.4
通讯作者：
Zong-Yi Li;Mark O. M. Tso;Hih-min Wong;Daniel T. Organisciakf
中科院分区：
文献类型：
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作者：
Zong-Yi Li;Mark O. M. Tso;Hih-min Wong;Daniel T. Organisciakf
据推测，抗坏血酸可能有助于保护视网膜免受光的氧化损伤。为了证实这一假设，作者通过光暴露后不同时间段的形态和形态计量学研究，比较了补充和不补充抗坏血酸的大鼠视网膜光损伤。在200到250英尺长的可见光蜡烛照射6小时后，两组之间在光感受器-视网膜色素上皮复合体中没有观察到显著的形态差异。在暴露24小时后的6到13天，接受抗坏血酸补充的大鼠的视网膜显示出比没有补充抗坏血酸的大鼠明显较轻的严重损伤。当比较补充和不补充抗坏血酸的大鼠时，视网膜的上象限和颞象限似乎对光损伤最敏感。这些结果表明，抗坏血酸可以改善大鼠视网膜的光损伤。
It has been postulated that ascorbic acid may help to protect the retina from oxidative insult by light. To confirm this hypothesis, the authors compared light-damaged retinas of rats with or without ascorbate supplement by morphologic and morphometric studies at different time periods after light exposure. No dramatic morphologic differences were observed in the photoreceptor-retinal pigment epithelium complex between the two groups six hr after light exposure to 200 to 250-foot candles of visible light. Six to 13 days after 24 hr of exposure, the retina of rats that received ascorbate supplement showed significantly less severe damage than the retina of unsupplemented rats. The superior and temporal quadrants of the retina appeared to be most susceptible to the light damage when comparing rats with or without ascorbate supplement. These findings suggested that ascorbate ameliorates the photic injury in rat retina.