High level of individual lipid profile and lipid ratio as a predictive marker of poor glycemic control in type-2 diabetes mellitus
High level of individual lipid profile and lipid ratio as a predictive marker of poor glycemic control in type-2 diabetes mellitus
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DOI：
10.2147/vhrm.s209830
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发表时间：
2019-01-01
影响因子：
2.9
通讯作者：
Rina, I. Ketut
中科院分区：
文献类型：
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作者：
Artha, I. Made Junior Rina;Bhargah, Agha;Rina, I. Ketut
导言：糖尿病常伴有不明原因的血脂异常。本研究的目的是探讨血脂谱和血脂比率作为预测2型糖尿病(T2 DM)患者血糖控制的生化模型的临床相关性。方法：这是一项在2018年至2019年在糖尿病中心桑拉综合医院和内科综合医院普里·拉哈贾综合医院招募的140名T2 DM患者的回顾性研究。人口学特征、糖化血红蛋白(HbA1c)和血脂谱用SPSS Version 25.0 for Windows进行记录和分析。然后样本被归类为良好的(HbA1c 7)血糖控制。结果：血糖控制不良组患者的血脂谱指标，如总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)和血脂比参数(LDL-C/高密度脂蛋白胆固醇(HDL-C)比值)均较高(p0.7)，其临界点、敏感性和特异性分别为4.68(77%；52%)和3.06(98%；56%)。风险分析模型显示，低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值参数是血糖控制不良发生的最有影响的危险因素(调整后的OR=38.76；95%CI：27.32-56.64；p
Introduction: Diabetes is often accompanied by undiagnosed dyslipidemia. The aim of the study is to investigate the clinical relevance of lipid profiles and lipid ratios as predictive biochemical models for glycemic control in patients with type 2 diabetes mellitus (T2DM).Methods: This is a retrospective study recruiting 140 patients with T2DM during a one-year period, 2018-2019, at the Diabetic Center Sanglah General Hospital and Internal Medicine Polyclinic Puri Raharja General Hospital. Demographic characteristics, glycosylated hemoglobin (HBA1c), and lipid profile were recorded and analyzed using SPSS version 25.0 for Windows. The sample is then classified into good (HBA1c 7) glycemic control. Risk analysis model, receiver operator characteristics (ROC) analysis, and correlation test were used to evaluate the association of HBA1c level with lipid profile and lipid ratio parameters.Result: Lipid profile findings such as total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and lipid ratio parameter (LDL-C to high-density lipoprotein cholesterol (HDL-C) ratio) were higher in patients in the poor glycemic control group (p0.7), with cutoff point, sensitivity, and specificity of 4.68 (77%; 52%) and 3.06 (98%; 56%) respectively. A risk analysis model shows that the LDL-C/HDL-C ratio parameter is the most influential risk factor in the occurrence of poor glycemic control (adjusted OR =38.76; 95% CI: 27.32-56.64; p