Determination of a novel B-Raf(V600E) and EGFR dual inhibitor in rat plasma by HPLC-MS/MS and its application in a pharmacokinetic study.
Determination of a novel B-Raf(V600E) and EGFR dual inhibitor in rat plasma by HPLC-MS/MS and its application in a pharmacokinetic study.
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HPLC-MS/MS 测定大鼠血浆中新型 B-Raf(V600E) 和 EGFR 双重抑制剂及其在药代动力学研究中的应用。
DOI：
10.1016/j.jpba.2016.06.049
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发表时间：
2016
影响因子：
3.4
通讯作者：
Hui
中科院分区：
文献类型：
--
作者：
Zhi;Jifeng Deng;Ying;Yu Chang;Hui
EGFR和B-RafV 600 E双重抑制是治疗B-RafV 600 E突变的结直肠癌患者的一种有前途的策略。先前，化合物3被设计和合成为新型B-RafV 600 E和EGFR双重抑制剂，其在基于激酶和细胞的测定中具有高度效力。本文建立了一种灵敏、快速的HPLC-MS/MS定量方法，并验证了该方法的有效性，可用于进一步评价化合物3在大鼠体内的药代动力学。
The EGFR and B-RafV600Edual inhibition is a promising strategy in treatment of colorectal cancer patients with B-RafV600Emutation. Previously, compound 3 was designed and synthesized as a novel B-RafV600Eand EGFR dual inhibitor with highly potency in both kinase and cell based assay. Herein, a sensitive and rapid HPLC–MS/MS quantitative method was developed and validated for the further pharmacokinetic evaluation of compound 3 in rats.
影响因子：
28.2
作者：
Corcoran RB;Ebi H;Turke AB;Coffee EM;Nishino M;Cogdill AP;Brown RD;Della Pelle P;Dias-Santagata D;Hung KE;Flaherty KT;Piris A;Wargo JA;Settleman J;Mino-Kenudson M;Engelman JA
通讯作者：
Engelman JA
DOI：
10.1016/j.jchromb.2005.05.037
发表时间：
2005-10-25
影响因子：
3
作者：
Churchwell, MI;Twaddle, NC;Doerge, DR
通讯作者：
Doerge, DR
影响因子：
45.3
作者：
Wagle, Nikhil;Emery, Caroline;Garraway, Levi A.
通讯作者：
Garraway, Levi A.