Stress Granules and ALS: A Case of Causation or Correlation?
Stress Granules and ALS: A Case of Causation or Correlation?
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DOI：
10.1007/978-3-319-89689-2_7
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Buchan, J. Ross
中科院分区：
文献类型：
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作者：
Fernandes, Nikita;Eshleman, Nichole;Buchan, J. Ross
肌萎缩侧索硬化症（Amyotrophic Lateral Sclerosis，ALS）是一种以运动神经元胞浆蛋白聚集为特征的神经退行性疾病。这些聚集体与ALS发病机制有关。最近的证据表明，应激颗粒可能有助于ALS蛋白聚集体的形成。在这里，我们总结了目前对应力颗粒的理解，重点是组装和清除。我们还评估了与ALS蛋白聚集体和疾病病理学有关的应激颗粒形成和动力学改变的证据。
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. These aggregates are linked to ALS pathogenesis. Recent evidence has suggested that stress granules may aid the formation of ALS protein aggregates. Here, we summarize current understanding of stress granules, focusing on assembly and clearance. We also assess the evidence linking alterations in stress granule formation and dynamics to ALS protein aggregates and disease pathology.