Digitizing protocols into single reactors for the one-pot synthesis of nanomaterials
Digitizing protocols into single reactors for the one-pot synthesis of nanomaterials
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DOI：
10.1016/j.matt.2023.05.029
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发表时间：
2023-07
期刊：
影响因子：
18.9
通讯作者：
Hsin-Herng Wang;J. S. Manzano;Philip J. Kitson;M. Mullin;Chang-Gen Lin;Igor I. Slowing;L. Cronin
中科院分区：
文献类型：
--
作者：
Hsin-Herng Wang;J. S. Manzano;Philip J. Kitson;M. Mullin;Chang-Gen Lin;Igor I. Slowing;L. Cronin
纳米材料表现出独特的性能，可根据其形态和成分进行调节。然而，广泛使用的方法可能会失败，由于不完整或假设的知识的合成协议。数字合成方法可以明确地捕获合成过程，包括所需的硬件、试剂输入和过程描述，从而增加可访问性并提高再现性。我们的方法通过将合成参数印刻到反应器的形态中来将合成过程编码到单个反应器中，所述反应器的形态使用化学描述语言χDL来描述。这种方法被合并到三个单一的反应器，自动化复杂的过程，如一次，逐滴，和顺序添加的合成八个时间分辨的CdSe量子点，CdSe@ZnSe核壳纳米粒子，和Pt-Fe 3 O 4 Janus纳米粒子，分别。这种将合成参数转化为反应器物理实例的方法能够以简单，可靠和可重复的方式实现纳米材料合成的自动化，使纳米材料可供来自不同领域的研究人员按需使用。
Nanomaterials exhibit unique properties that are tunable depending on their morphology and composition. However, widely used methods can fail due to incomplete or assumed knowledge of the synthesis protocol. A digital synthesis method could unambiguously capture the synthesis process, including required hardware, reagent inputs, and process description, thereby increasing accessibility and improving reproducibility. Our method encodes synthetic procedures into single reactors by imprinting synthetic parameters to the reactor's morphology, which are described using a chemical description language, χDL. This approach is consolidated into three single reactors that automate complex processes such as one-time, dropwise, and sequential addition for the synthesis of eight time-resolved CdSe quantum dots, CdSe@ZnSe core-shell nanoparticles, and Pt-Fe3O4Janus nanoparticles, respectively. This method of translating synthetic parameters into physical instances of a reactor enables the automation of nanomaterial synthesis in a simple, reliable, and reproducible manner, making nanomaterials accessible to researchers from various fields on demand.