Exposure to environmental tobacco smoke is associated with increased risk for multiple sclerosis
Exposure to environmental tobacco smoke is associated with increased risk for multiple sclerosis
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DOI：
10.1177/1352458511399610
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发表时间：
2011-07-01
影响因子：
5.8
通讯作者：
Alfredsson, L.
中科院分区：
文献类型：
--
作者：
Hedstrom, A. K.;Baarnhielm, M.;Alfredsson, L.
背景：吸烟一直与多发性硬化的风险增加有关。然而，数据一直不一致的影响被动smoking.Objective：其目的是估计被动吸烟对多发性硬化症的风险的影响。方法：一个以人口为基础的病例对照研究，使用多发性硬化症的事件的情况下，在瑞典进行，研究人群仅限于受试者从未吸烟（695例，1635对照）。通过使用logistic回归计算比值比和95%置信区间，比较暴露于被动吸烟的从不吸烟者与从未暴露于被动吸烟的从不吸烟者之间多发性硬化症的发病率。在被动吸烟的从不吸烟者中，多发性硬化症的风险增加（OR 1.3，95%CI 1.1-1.6）与从未接触过的从不吸烟者相比。结论：暴露于环境烟草烟雾与多发性硬化症的风险增加有关。由于吸烟（而不是使用湿鼻烟形式的口腔烟草）与多发性硬化症的风险增加有关，我们认为被动吸烟的关键影响可能是肺部刺激的结果。因此，进一步的研究将是有价值的，以澄清其他形式的肺刺激，如空气污染，是否有助于触发多发性硬化症。
Background: Tobacco smoking has consistently been associated with increased risk for multiple sclerosis. However, data has been inconsistent regarding the influence of passive smoking.Objective: The aim was to estimate the influence of passive smoking on the risk for multiple sclerosis.Methods: A population-based case-control study using incident cases of multiple sclerosis was performed in Sweden, and the study population was restricted to subjects who had never smoked (695 cases, 1635 controls). The incidence of multiple sclerosis among never-smokers who had been exposed to passive smoking was compared with that of never-smokers who had never been exposed by calculating the odds ratio with a 95% confidence interval employing logistic regression.Results: The risk for multiple sclerosis was increased among never-smokers who had been exposed to passive smoking (OR 1.3, 95% Cl 1.1-1.6) compared to never-smokers who had never been exposed. The risk increased with increasing duration of exposure (p = 0.003).Conclusions: Exposure to environmental tobacco smoke is associated with an increased risk for multiple sclerosis. Since smoking, but not usage of oral tobacco in the form of moist snuff, is associated with increased risk for multiple sclerosis, we consider that the critical effects of passive smoking may be the result of irritations in the lungs. Hence, further studies would be valuable in order to clarify whether other forms of lung irritation, such as air pollution, contribute to the triggering of multiple sclerosis.