Heart failure and diabetes: role of ATM.
Heart failure and diabetes: role of ATM.
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DOI：
10.1016/j.coph.2020.06.007
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发表时间：
2020-10
影响因子：
4
通讯作者：
Singh K
中科院分区：
文献类型：
--
作者：
Wingard MC;Frasier CR;Singh M;Singh K
在美国，心力衰竭是导致死亡的主要原因。糖尿病，也被称为糖尿病（DM），会成倍地增加患心力衰竭的风险。糖尿病引起的氧化应激增加和代谢功能障碍可导致DNA损伤和糖尿病性心肌病的发生。Ataxia毛细血管扩张症突变激酶（ATM）是一种DNA损伤反应蛋白，其主要核功能是在双链DNA断裂时调节细胞周期进程，作为氧化还原传感器，促进DNA修复。ATM缺乏与胰岛素抵抗和糖尿病的发展有关。因此，患有共济失调毛细血管扩张症（一种罕见的常染色体隐性遗传病）的患者发生心力衰竭的风险增加。本综述的主要目的是总结与DM和ATM缺乏相关的共同代谢和心脏异常，重点是心力衰竭的发展。
Heart failure is a leading cause of death in the United States. Diabetes, also known as diabetes mellitus (DM), exponentially increases the risk of heart failure. The increase in oxidative stress and metabolic dysfunction caused by DM can lead to DNA damage and the development of diabetic cardiomyopathy. Ataxia telangiectasia mutated kinase (ATM) is a DNA damage response protein with a primary nuclear function to regulate cell cycle progression in response to double-strand DNA breaks, acts as a redox sensor, and facilitates DNA repair. ATM deficiency associates with the development of insulin resistance and DM. Consequently, patients with Ataxia telangiectasia, a rare autosomal recessive disorder, have an increased risk of developing heart failure. The main objective of this review is to summarize the shared metabolic and cardiac abnormalities associated with DM and ATM deficiency, with a focus on the development of heart failure.
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影响因子：
5.4
作者：
Daniel LL;Daniels CR;Harirforoosh S;Foster CR;Singh M;Singh K
通讯作者：
Singh K
DOI：
10.1111/dme.13037
发表时间：
2016-03
期刊：
Diabetic medicine : a journal of the British Diabetic Association
影响因子：
--
作者：
Connelly PJ;Smith N;Chadwick R;Exley AR;Shneerson JM;Pearson ER
通讯作者：
Pearson ER
影响因子：
4.6
作者：
Isfort, Michael;Stevens, Sarah C. W.;Schaffer, Stephen;Jong, Chian Ju;Wold, Loren E.
通讯作者：
Wold, Loren E.
影响因子：
13.8
作者：
Ditch, Scott;Paull, Tanya T.
通讯作者：
Paull, Tanya T.
影响因子：
3.3
作者：
Felício JS;Koury CC;Carvalho CT;Abrahão Neto JF;Miléo KB;Arbage TP;Silva DD;de Oliveira AF;Peixoto AS;Figueiredo AB;Ribeiro Dos Santos ÂK;Yamada ES;Zanella MT
通讯作者：
Zanella MT