Taming dendritic cells with TIM-3: another immunosuppressive strategy used by tumors.
Taming dendritic cells with TIM-3: another immunosuppressive strategy used by tumors.
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DOI：
10.2217/imt.12.126
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发表时间：
2012-12
期刊：
影响因子：
2.8
通讯作者：
Selvaraj P
中科院分区：
文献类型：
--
作者：
Patel J;Bozeman EN;Selvaraj P
TIM-3在肿瘤相关树突状细胞（TADCs）上表达的鉴定为肿瘤介导的免疫抑制的另一个方面提供了见解。TIM-3在肿瘤浸润性T细胞中的作用已被很好地表征，但其在TADCs中的作用以前并不为人所知。本文证实TIM-3主要由TADCs表达，其与核蛋白HMGB1的相互作用抑制了核酸介导的有效抗肿瘤免疫反应的激活。作者能够证明TIM-3与HMGB1的相互作用阻止了核酸进入内体囊泡的定位。此外，发现化疗在抗tim -3 mAb处理的小鼠或所有dc缺失的小鼠中更有效，这表明TADCs在抑制肿瘤消退中发挥了重要作用。综上所述，这些发现确定TIM-3是在临床环境中与DNA疫苗和/或免疫原性化疗联合诱导抗肿瘤免疫的潜在靶点。
The identification of TIM-3 expression on tumor associated dendritic cells (TADCs) provides insight into another aspect of tumor-mediated immunosuppression. The role of TIM-3 has been well characterized on tumor-infiltrating T cells, however its role on TADCs was not previously known. The current paper demonstrated that TIM-3 was predominantly expressed by TADCs and its interaction with the nuclear protein HMGB1 suppressed nucleic acid mediated activation of an effective antitumor immune response. The authors were able to show that TIM-3 interaction with HMGB1 prevented the localization of nucleic acids into endosomal vesicles. Furthermore, chemotherapy was found to be more effective in anti-TIM-3 mAb treated mice or mice depleted of all DCs which indicated that significant role played by TADCs inhibiting tumor regression. Taken together, these findings identify TIM-3 as a potential target for inducing antitumor immunity in conjunction with DNA vaccines and/or immunogenic chemotherapy in clinical settings.
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影响因子：
30.5
作者：
Chiba, Shigeki;Baghdadi, Muhammad;Akiba, Hisaya;Yoshiyama, Hironori;Kinoshita, Ichiro;Dosaka-Akita, Hirotoshi;Fujioka, Yoichiro;Ohba, Yusuke;Gorman, Jacob V.;Colgan, John D.;Hirashima, Mitsuomi;Uede, Toshimitsu;Takaoka, Akinori;Yagita, Hideo;Jinushi, Masahisa
通讯作者：
Jinushi, Masahisa
DOI：
10.1084/jem.20082429
发表时间：
2008-11-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hafler DA;Kuchroo V
通讯作者：
Kuchroo V
影响因子：
64.8
作者：
Monney, L;Sabatos, CA;Kuchroo, VK
通讯作者：
Kuchroo, VK
DOI：
10.1084/jem.20081398
发表时间：
2008-11-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jones RB;Ndhlovu LC;Barbour JD;Sheth PM;Jha AR;Long BR;Wong JC;Satkunarajah M;Schweneker M;Chapman JM;Gyenes G;Vali B;Hyrcza MD;Yue FY;Kovacs C;Sassi A;Loutfy M;Halpenny R;Persad D;Spotts G;Hecht FM;Chun TW;McCune JM;Kaul R;Rini JM;Nixon DF;Ostrowski MA
通讯作者：
Ostrowski MA
Tim-3 通路控制丙型肝炎病毒感染期间的调节性和效应 T 细胞平衡
DOI：
10.4049/jimmunol.1200162
发表时间：
2012-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Moorman JP;Wang JM;Zhang Y;Ji XJ;Ma CJ;Wu XY;Jia ZS;Wang KS;Yao ZQ
通讯作者：
Yao ZQ