DISTINCT GENETIC-LOCI CONTROL DEVELOPMENT OF BENIGN AND MALIGNANT SKIN TUMORS IN MICE
DISTINCT GENETIC-LOCI CONTROL DEVELOPMENT OF BENIGN AND MALIGNANT SKIN TUMORS IN MICE
复制标题
DOI：
10.1038/ng0895-424
复制
发表时间：
1995-08-01
期刊：
影响因子：
30.8
通讯作者：
BALMAIN, A
中科院分区：
文献类型：
--
作者：
NAGASE, H;BRYSON, S;BALMAIN, A
小鼠对化学诱导皮肤癌的遗传易感性是由多个不相关的遗传位点控制的。繁殖小家鼠具有显性抗性基因，使其对易感小家鼠株的种间F-1杂交种具有抗性。利用Mapmaker/QTL分析和多元回归分析，我们在小鼠5号和7号染色体上定位了3个主要的抗性位点。7号染色体上至少有两个独立的位点主要在良性肿瘤的发展过程中发挥作用，对肿瘤的进展影响很小。另一方面，5号染色体上的单个基因座可能同时影响恶性肿瘤的早期和晚期。结果表明，良性和恶性肿瘤在很大程度上受独立的遗传控制。
Genetic susceptibility to chemically induced skin cancer in mice is controlled by multiple unlinked genetic loci. Mus spretus mice have dominant resistance genes which confer resistance to interspecific F-1 hybrids with susceptible Mus musculus strains. We have mapped three major resistance loci using a combination of Mapmaker/QTL analysis and multiple regression analysis to mouse chromosomes 5 and 7. At least two independent loci on chromosome 7 exert their effects primarily during benign tumour development and have very little influence on tumour progression. On the other hand, probably a single locus on chromosome 5 affects both early and late stages of malignancy. The results indicate that benign and malignant tumours are largely under independent genetic control.