The expanded cattle KIR genes are orthologous to the conserved single-copy KIR3DX1 gene of primates
The expanded cattle KIR genes are orthologous to the conserved single-copy KIR3DX1 gene of primates
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DOI：
10.1007/s00251-007-0214-x
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发表时间：
2007-06-01
期刊：
影响因子：
3.2
通讯作者：
Parham, Peter
中科院分区：
文献类型：
--
作者：
Guethlein, Lisbeth A.;Abi-Rached, Laurent;Parham, Peter
牛是唯一有报道称杀伤细胞免疫球蛋白样受体（KIR）基因扩增的非灵长类动物。我们分析了牛 KIR 序列，以确定它们与灵长类 KIR 的两个不同谱系的关系：一个包含功能未知的 KIR3DX1 基因，第二个包含所有其他灵长类 KIR 基因，这些基因编码可变的主要组织相容性复合物 I 类受体。系统发育和重复元素分析表明，牛 KIR 细分为与灵长类 KIR 相同的两个谱系。与灵长类动物不同，可变且可能有功能的牛 KIR 谱系对应于灵长类 KIR 的 KIR3DX1 谱系，而灵长类 KIR 的可变谱系在牛中由一个 KIR 基因和一个相关基因片段代表。
Cattle are the only non-primate species for which expansion of the killer cell immunoglobulin-like receptor (KIR) genes has been reported. We analyzed cattle KIR sequences to determine their relationship to the two divergent lineages of primate KIR: one comprising the KIR3DX1 gene of unknown function, the second comprising all other primate KIR genes, which encode variable major histocompatibility complex class I receptors. Phylogenetics and analysis of repetitive elements shows that cattle KIR subdivide into the same two lineages as primate KIR. Unlike the primates, the lineage of variable and likely functional cattle KIR corresponds to the KIR3DX1 lineage of primate KIR, whereas the variable lineage of primate KIR is represented in cattle by one KIR gene and a related gene fragment.