Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study
Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study
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DOI：
10.1086/338144
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发表时间：
2002-01-01
影响因子：
9.8
通讯作者：
Province, MA
中科院分区：
文献类型：
--
作者：
Feitosa, MF;Borecki, IB;Province, MA
肥胖是许多慢性疾病的危险因素，包括葡萄糖耐受不良、脂质紊乱、高血压和冠心病。尽管身体质量指数（BMI）是一种反映脂肪量、瘦肉量和体型的异质性表型，但一些研究已经提供了一两个主要基因位点对这一复杂性状的变异有贡献的证据。我们试图从国家心脏、肺和血液研究所家庭心脏研究的数据中找出对BMI有潜在影响的基因座。两个互补样本：(a)来自317个兄弟姐妹的1184名受试者，其中243个标记由犹他州分子遗传学实验室（UMGL）分型；(b)来自401个三代家庭的3027名受试者，其中404个标记由哺乳动物基因分型服务（MGS）分型。使用基于方差成分的连锁方法对每个样本和组合样本进行基因组扫描，其中每个分析的标记被放置在一个共同的遗传图谱上。每个样本的7q32.3染色体存在连锁，多点LOD评分最高为4.7分(P
Obesity is a risk factor for many chronic diseases, including glucose intolerance, lipid disorders, hypertension, and coronary heart disease. Even though the body-mass index (BMI) is a heterogeneous phenotype reflecting the amount of fat, lean mass, and body build, several studies have provided evidence of one or two major loci contributing to the variation in this complex trait. We sought to identify loci with potential influence on BMI in the data obtained from National Heart, Lung, and Blood Institute Family Heart Study. Two complementary samples were studied: (a) 1, 184 subjects in 317 sibships, with 243 markers typed by the Utah Molecular Genetics Laboratory (UMGL) and (b) 3,027 subjects distributed among 401 three-generation families, with 404 markers typed by the Mammalian Genotyping Service (MGS). A genome scan using a variance-components-based linkage approach was performed for each sample, as well as for the combined sample, in which the markers from each analysis were placed on a common genetic map. There was strong evidence for linkage on chromosome 7q32.3 in each sample: the maximum multipoint LOD scores were 4.7 (P