Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis.
Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis.
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DOI：
10.1155/2015/740357
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发表时间：
2015
影响因子：
4.6
通讯作者：
Šenolt L
中科院分区：
文献类型：
--
作者：
Cerezo LA;Kuklová M;Hulejová H;Vernerová Z;Kaspříková N;Veigl D;Pavelka K;Vencovský J;Šenolt L
目标。前颗粒蛋白（PGRN）与类风湿关节炎（RA）的发病机制有关。本研究的目的是评估PGRN与RA疾病活动性之间的关系。方法。评估RA患者（n = 47）、OA患者（n = 42）和健康对照组（n = 41）的PGRN水平。对滑膜组织中的PGRN进行免疫组化分析。研究PGRN与c反应蛋白（CRP）、疾病活动性评分（DAS28-CRP）、健康评估问卷（HAQ）的相关性。结果。与健康对照组相比，RA和OA患者的循环PGRN升高（227.1±100.2和221.5±102.5分别比128.1±34.7 ng/mL; P < 0.001）。RA患者滑液中PGRN水平高于OA患者（384.5±275.3 vs 241.4±165.2 ng/mL; P = 0.002）。PGRN在RA患者滑膜组织中的表达明显上调，尤其是在炎症浸润处。RA患者血清PGRN水平与DAS28 （r = 0.327, P = 0.049）和HAQ评分（r = 0.323, P = 0.032）相关，而滑液PGRN仅与HAQ相关（r = 0.310, P = 0.043）。PGRN水平与CRP或自身抗体无关。结论。本研究表明，PGRN在局部炎症部位的表达增加，以及PGRN水平与RA患者疾病活动性和功能损害之间的关联。
Objective. Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. Methods. PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical analysis of PGRN in synovial tissues was performed. The association between PGRN and C-reactive protein (CRP), disease activity score (DAS28-CRP), and health assessment questionnaire (HAQ) was studied. Results. Circulating PGRN was elevated in patients with RA and OA compared to healthy controls (227.1 ± 100.2 and 221.5 ± 102.5 versus 128.1 ± 34.7 ng/mL; P < 0.001). Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002). PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates. Serum PGRN levels correlated with DAS28 (r = 0.327, P = 0.049) and HAQ score (r = 0.323, P = 0.032), while synovial fluid PGRN correlated only with HAQ (r = 0.310, P = 0.043) in patients with RA. PGRN levels were not associated with CRP or autoantibodies. Conclusions. This study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with RA.