The Gln27Glu Polymorphism in β2-Adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis
The Gln27Glu Polymorphism in β2-Adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis
复制标题
DOI：
10.1186/1476-511x-9-90
复制
发表时间：
2010-08-25
影响因子：
4.5
通讯作者：
Al-zhrani, Sabah
中科院分区：
文献类型：
--
作者：
Daghestani, Maha H.;Warsy, Arjumand;Al-zhrani, Sabah
背景资料：β 2肾上腺素能受体（β 2 AR）基因多态性谷氨酰胺27谷氨酸（Gln 27 Glu）和Arg 16 Gly与部分人群肥胖及肥胖相关疾病有关。我们评估了Gln 27 Glu多态性β 2 AR基因在肥胖的沙特人口调查β 2 AR基因与肥胖和其他相关的metabolic parameters.Design的关联：我们研究了可能的关联β 2 AR基因的Gln 27 Glu与体重指数（BMI），人体测量和其他代谢参数。β 2 AR基因多态性（Gln 27 Glu）通过PCR产物测序确定。根据体重指数将受试者分为正常体重、超重和肥胖三组。结果：肥胖组Glu 27等位基因频率无显著性差异，但Glu 27纯合子（Glu/Glu）多于Gln 27杂合子和Gln/Gln纯合子，且甘油三酯、瘦素和胰岛素浓度均高于Gln 27杂合子和Gln/Gln纯合子。在这项研究中，我们能够提供证据的影响β 2AR基因的Gln 27 Glu遗传变异的脂质表型，胰岛素和瘦素水平在沙特人口。
Background: beta 2-adrenoceptor (beta 2AR) gene polymorphism glutamine 27 glutamic acid (Gln27Glu) and Arg16Gly were reported to have an association with obesity and obesity related disorders in some population. We evaluated Gln27Glu polymorphism in the beta 2AR gene in obese Saudi populations to investigate the association of beta 2AR gene with obesity and other related metabolic parameters.Design: We studied possible association of Gln27Glu in beta 2AR gene with body mass index (BMI), anthropometric measurements and other metabolic parameters. The beta 2AR gene polymorphism (Gln27Glu) was identified by sequencing PCR products representing locus of interest. Based on BMI, the subjects were divided into three groups, normal weight, overweight and obese. The genotype and allele frequency were calculated separately for each group.Results: The allelic frequency of Glu27 did not differ amongst the three groups, though the Glu27 homozygote (Glu/Glu) were more in obese subjects and had higher concentration of triglyceride, leptin and insulin compared to in the Gln27 heterozygotes and Gln/Gln homozygotes.Conclusions: In this study we were able to provide evidence on the influence of Gln27Glu genetic variant of beta 2AR gene on lipid phenotypes, insulin and leptin levels in the Saudi populations.