Stem cell-based organ replacements-Airway and lung tissue engineering
Stem cell-based organ replacements-Airway and lung tissue engineering
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DOI：
10.1053/j.sempedsurg.2014.04.002
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发表时间：
2014-06-01
影响因子：
1.7
通讯作者：
Birchall, Martin A.
中科院分区：
文献类型：
--
作者：
Fishman, Jonathan M.;Lowdell, Mark;Birchall, Martin A.
组织工程需要使用接种在支架上的细胞，通常与生物活性分子结合，以再生或替换组织。近年来，干细胞生物学和生物材料领域取得了重大进展，导致气道组织工程的一些令人兴奋的发展，包括首次在人体中使用基于干细胞的组织工程化气管替代物。此外，支架生物学和脱细胞化领域的最新进展为移植患者提供了不使用免疫抑制剂的可能性。(C)2014爱思唯尔公司All rights reserved.
Tissue engineering requires the use of cells seeded onto scaffolds, often in conjunction with bioactive molecules, to regenerate or replace tissues. Significant advances have been made in recent years within the fields of stem cell biology and biomaterials, leading to some exciting developments in airway tissue engineering, including the first use of stem cell-based tissue-engineered tracheal replacements in humans. In addition, recent advances within the fields of scaffold biology and decellularization offer the potential to transplant patients without the use of immunosuppression. (C) 2014 Elsevier Inc. All rights reserved.