Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics
Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics
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DOI：
10.1038/ijo.2011.27
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发表时间：
2011-04-01
影响因子：
4.9
通讯作者：
Jess, T.
中科院分区：
文献类型：
--
作者：
Ajslev, T. A.;Andersen, C. S.;Jess, T.
目的：要调查交付模式是否（阴道与剖腹产）、孕妇孕前体重指数（BMI）和早期抗生素暴露（< 6个月）影响儿童7岁时超重的风险，因此支持以下假设：影响肠道微生物群的建立和多样性的环境因素与以后超重的风险有关。设计：纵向，前瞻性研究与措施的暴露在婴儿期和随访7 years.Methods：共28 354从丹麦国家出生队列的母子二人组，母亲孕前BMI，分娩方式和抗生素管理在婴儿期的信息进行了评估。结果：分娩方式与儿童期超重无显著相关性（OR：1.18，95%可信区间（CI）：0.95-1.47）。出生后6个月内使用抗生素导致体重正常母亲的儿童超重风险增加（OR：1.54，95%CI：1.09-2.17），超重母亲的儿童超重风险降低（OR：0.54，95%CI：0.30-0.98）。结论：分娩方式、母亲孕前BMI和婴儿期抗生素等因素对儿童期超重的发生有影响。这种影响可能是通过对微生物群的建立和多样性的影响来解释的。International Journal of Obesity（2011）35，522-529; doi：10.1038/ijo.2011.27; 2011年3月8日在线发表
Objective: To investigate whether delivery mode (vaginal versus by caesarean section), maternal pre-pregnancy body mass index (BMI) and early exposure to antibiotics (< 6 months of age) influence child's risk of overweight at age 7 years, hence supporting the hypotheses that environmental factors influencing the establishment and diversity of the gut microbiota are associated with later risk of overweight.Design: Longitudinal, prospective study with measure of exposures in infancy and follow-up at age 7 years.Methods: A total of 28 354 mother-child dyads from the Danish National Birth Cohort, with information on maternal pre-pregnancy BMI, delivery mode and antibiotic administration in infancy, were assessed. Logistic regression analyses were performed with childhood height and weight at the 7-year follow-up as outcome measures.Results: Delivery mode was not significantly associated with childhood overweight (odds ratio (OR): 1.18, 95% confidence interval (CI): 0.95-1.47). Antibiotics during the first 6 months of life led to increased risk of overweight among children of normal weight mothers (OR: 1.54, 95% CI: 1.09-2.17) and a decreased risk of overweight among children of overweight mothers (OR: 0.54, 95% CI: 0.30-0.98). The same tendency was observed among children of obese mothers (OR: 0.85, 95% CI: 0.41-1.76).Conclusion: The present cohort study revealed that a combination of early exposures, including delivery mode, maternal pre-pregnancy BMI and antibiotics in infancy, influences the risk of overweight in later childhood. This effect may potentially be explained by an impact on establishment and diversity of the microbiota. International Journal of Obesity (2011) 35, 522-529; doi: 10.1038/ijo.2011.27; published online 8 March 2011